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Low frequency of bcl-2 rearrangement in HCV-associated non-Hodgkin's lymphoma tissue

Leukemia volume 17, pages 1433–1436 (2003)Cite this article

TO THE EDITOR

The bcl-2 translocation is a genetic alteration involved in lymphomagenesis, especially in lymphomas for which an antigen-driven pathogenetic mechanism has been hypothesized, such as follicular lymphoma (FL) and salivary gland non-Hodgkin's lymphoma (NHL) in patients with Sjögren's syndrome. Previous studies of B-cell lymphoproliferation in hepatitis C virus (HCV)-infected patients are consistent with an antigen-driven process and support a role for antigens associated with HCV in chronic stimulation of B-cell proliferation, particularly in individuals with type II mixed cryoglobulinemia (MC) syndrome.1

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Figure 1

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Acknowledgements

We thank Patrick M Navolanic for help with the manuscript and Renato Talamini for statistical analysis. Funding was from the Italian Association for Cancer Research.

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  1. Massimo Libra and Valli De Re: Both these authors contributed equally to this manuscript.

Authors and Affiliations

  1. Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy

    Massimo Libra, Valli De Re, Daniela Gasparotto & Alessandra Marzotto

  2. Department of Biomedical Science, Clinical Pathology and Molecular Oncology Section, University of Catania, Italy

    Massimo Libra & Franca Stivala

  3. Division of Rheumatology, DPMSC, University of Udine, Italy

    Salvatore De Vita

  4. Division of Pathology, Centro di Riferimento Oncologico, Avriano, Italy

    Annunziata Gloghini, Antonino Carbone & Mauro Boiocchi

  5. Division of Medical Oncology A, Centro di Riferimento Oncologico, Aviano, Italy

    Maurizio Rupolo

  6. Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico Aviano, Pordenone, Italy

    Massimo Degan

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  1. Massimo Libra
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Libra, M., De Re, V., De Vita, S. et al. Low frequency of bcl-2 rearrangement in HCV-associated non-Hodgkin's lymphoma tissue. Leukemia 17, 1433–1436 (2003). https://doi.org/10.1038/sj.leu.2402968

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