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Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities

Leukemia volume 16, pages 2177–2184 (2002)Cite this article

Abstract

New insights into causative factors for the development of myelodysplasia (MDS) and acute myeloid leukemia (AML), with associations to specific cytogenetic and genetic abnormalities have been obtained primarily from studies of patients with the therapy-related subsets of the two diseases. Current knowledge now makes it possible to distinguish between at least seven major genetic subgroups of MDS and AML, and has directed research towards more specific causative factors also for de novo MDS and AML.

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Acknowledgements

Supported by grants from the Danish Cancer Society and HS Forskningspulje 1997.

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  1. Department of Clinical Genetics, Cytogenetic Laboratory, Section of Hematology/Oncology, Juliane Marie Center, University Hospital, Rigshospitalet, Copenhagen, Denmark

    J Pedersen-Bjergaard, DH Christiansen, MK Andersen & F Skovby

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  1. J Pedersen-Bjergaard
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Pedersen-Bjergaard, J., Christiansen, D., Andersen, M. et al. Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities. Leukemia 16, 2177–2184 (2002). https://doi.org/10.1038/sj.leu.2402764

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