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  • European Union Concerted Action Workshop on 11q23
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Ten novel 11q23 chromosomal partner sites

Leukemia volume 12, pages 811–822 (1998)Cite this article

Abstract

The MLL gene located at 11q23 has been described as a ‘promiscuous’ gene due its involvement with a large number of genetic partners. The EU Concerted Action Workshop on 11q23 provided 550 cases for study of which 82 showed abnormalities which did not involve the established translocations or deletion of 11q23. In these ‘other’ cases, which included inversions and duplications, 11q23 was found to be involved with 25 chromosome partners of which 10 had not been previously reported. These were 1q31, 4p11, 6q13, 8q21, 10q22, 10q25, 11q11, 11q21, 13q34 and 18q23. This study demonstrated the value of the Workshop, in confirming the diversity of chromosomal partner sites involved with 11q23 and in the identification of new partners.

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Authors and Affiliations

  1. Department of Haematology, Leukaemia Research Fund United Kingdom Karyotype Database in Acute Lymphoblastic Leukaemia, Royal Free Hospital School of Medicine, London, UK

    CJ Harrison, R Clark, AV Moorman & LM Secker-Walker

  2. Institute of Haematology, Ferrara, Italy

    A Cuneo

  3. Department of Clinical Genetics, Lund University Hospital, Sweden

    B Johansson

  4. Laboratoire de Cytogénétique Hématologique, Institut Paoli-Calmettes et INSERM U119, Marseilles

    M Lafage-Pochitaloff

  5. Laboratoire de Cytogénétique, Faculte de Medecine, Dijon, France

    F Mugneret

Authors
  1. CJ Harrison
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  2. A Cuneo
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  3. R Clark
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  4. B Johansson
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  5. M Lafage-Pochitaloff
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  6. F Mugneret
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  7. AV Moorman
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  8. LM Secker-Walker
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Cite this article

Harrison, C., Cuneo, A., Clark, R. et al. Ten novel 11q23 chromosomal partner sites. Leukemia 12, 811–822 (1998). https://doi.org/10.1038/sj.leu.2401017

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  • DOI: https://doi.org/10.1038/sj.leu.2401017

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