ABOUT THE JOURNAL

Aims and scope of journal

Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology (USCAP) whose prime mission is to publish original manuscripts and review articles in the broad area of translational and basic research as is related to experimental pathology. Manuscripts dealing with research relevance to human clinical disease are given high priority along with those which explore mechanism and etiology of disease processes.

The journal features the following types of papers:

• Editorial
• Inside Lab Invest
• Pathobiology in Focus
• Perspective
• Letter to the Editor
• Minireview
• Research Articles
• Technical Reports

Impact Factor

Impact Factor: 4.580*

Rank:
8/68 in Pathology
9/82 in Medicine, Research & Experimental

*2008 Journal Citation Report (Thomson Reuters, 2009)

Abstracted/indexed in

Index Medicus
Current Contents (Life Sciences, Science Citation Index, Research Alert, ISI/BioMed)
Excerpta Medica
Biosciences Information Service
Reference Update/Research Information Services

ISSN and eISSN

The international standard serial number (ISSN) for Laboratory Investigation is 0023-6837 and the electronic international standard serial number (eISSN) is 1530-0307.

Editors

Editor-in-Chief

Gene P. Siegal MD, PhD, is an experimental and diagnostic musculoskeletal pathologist whose research focuses on Cancer Biology. He is the Immediate Past President of the Arthur Purdy Stout Society of Surgical Pathologists, Past Chair of the Fellow Council of the American Society of Clinical Pathology and he has served or is serving on the Executive Committees of the Association of Directors of Anatomic and Surgical Pathology, the American Society for Investigative Pathology, and the American Society of Clinical Pathology. He is currently the Chair of the Intersociety Pathology Council and a long-time participant in the academic life of the Academy.

His research interests are tumor-matrix interactions during angiogenesis and tumor invasion and metastasis. Efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on cancer progression in humans. In separate studies he and his associates have been exploring how carbohydrate associated cell surface molecules modulate tumor cell interactions with the environment surrounding cancer cells. He has also participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms. His most recently funded NIH grant involves the development of a conditionally replicating canine adenovirus model for the study host-vector interactions for more effective antitumor oncolytic effects using osteosarcoma as the model.

Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions, a field in which he is a recognized world authority, having shared with M.J. Pitt, the Farrell Prize of the International Skeletal Society in 2002. He is the author of nearly 600 peer-reviewed manuscripts, book chapters, abstracts and other professional writings.

Senior Associate Editors

Robert W. Hardy, PhD, is an Associate Professor of Pathology at The University of Alabama at Birmingham (UAB), where he is also Section Head of Clinical Chemistry. He has secondary appointments in the departments of Physiology and Biophysics, Nutrition Sciences and Department of Critical and Diagnostic Care. He received the Ph.D. degree from the University of Toronto, Ontario, Canada in 1988 and completed post doctoral fellowships at Washington University and UAB. He joined the faculty at UAB in 2001. He is a Diplomate of the American Board of Clinical Chemistry, as well as member of the American Board of Clinical Chemistry, and a Fellow of the National Academy of Clinical Biochemistry. He has authored over 50 peer-reviewed publications, reviews, book chapters and serves on grant review panels for the NIH, Department of Defense, and the American Institute for Cancer Research. Research in his laboratory is focused on understanding how individual fatty acids affect cancer progression and insulin resistance at the cellular and molecular level.

Brian Rubin, MD, PhD, is an Associate Professor of Pathology of the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Director of Soft Tissue Pathology at the Cleveland Clinic and a member of the Department of Molecular Genetics of the Lerner Research Institute and Taussig Cancer Center. He earned MD and PhD degrees from Cornell University Medical School in New York in 1995, and trained in anatomic pathology and soft tissue pathology at Brigham and Women's Hospital, Boston, MA. He is certified in Anatomic Pathology by the American Board of Pathology and has been an USCAP member since 1997. He has authored over 80 peer-reviewed publications, editorials, reviews and book chapters. His laboratory research is focused on genomics of bone and soft tissue neoplasms, establishing cancer models, and in developing targeted therapies for the treatment of cancer.

Managing Editor

Catherine M. Ketcham, PhD, has been Managing Editor of Laboratory Investigation since 2003. She conducts independent research in the field of bibliometrics and is also the Technical Director of the University of Florida Molecular Tissue Bank. She earned her Ph.D. degree in Biochemistry and Molecular Biology from the University of Florida. Her postdoctoral studies were carried out at Washington University in St. Louis School of Medicine. She then spent seven years in the San Diego biotechnology community focusing on manufacturing issues and business development. Subsequently, she was a research and development scientist associated with the University of Florida Interdisciplinary Center for Biotechnology Research and the Sid Martin Biotechnology Development Incubator before joining the Pathology department.

Associate Editors

Sylvia L Asa, MD, PhD
Toronto, ON, Canada

Ann Chambers, PhD
London, ON, Canada

Kathleen R Cho, MD
Ann Arbor, MI

James M Crawford, MD, PhD
Manhasset, NY

David T Curiel, MD, PhD
Birmingham, AL

Mark W Lingen, DDS, PhD
Chicago, IL

Anirban Maitra, MBBS
Baltimore, MD

Giuliano Ramadori, MD, PhD
Goettingen, Germany

Jae-Kyu Roh, MD
Seoul, Korea

Akihiro Umezawa, MD, PhD
Tokyo, Japan

Editorial Board

Clara Abraham, Chicago, IL, USA
Charles Alpers, Seattle, WA, USA
Gianfranco D. Alpini, Temple, TX, USA
Robert A. Anders, Baltimore, MD, USA
Kenneth Bernstein, Atlanta, GA, USA
Raul Braylan, Gainesville, FL, USA
Martha Campbell-Thompson, Gainesville, FL, USA
Anthony Chang, Chicago, IL, USA
William B. Coleman, Chapel Hill, NC, USA
Robert B. Colvin, Boston, MA, USA
Bogdan A. Czerniak, Houston, TX, USA
Michael B. Dwinell, Madison, WI, USA
Agnes B. Fogo, Nashville, TN, USA
Stephen Galli, Stanford, CA, USA
A. Julian Garvin, Winston-Salem, NC, USA
Andrew Gewirtz, Atlanta, GA, USA
James D. Gorham, Lebanon, NH, USA
Avrum Gotleib, Toronto, ON, Canada
Allen M. Gown, Seattle, WA, USA
Michael N. Hart, Madison, WI, USA
Tong-Chuan He, Chicago, IL, USA
William F. Hickey, Lebanon, NH, USA
Peter M. Howley, Boston, MA, USA
Elaine Jaffe, Bethesda, MD, USA
J. Charles Jennette, Chapel Hill, NC, USA
Agnes Kane, Providence, RI, USA
Yashpal S. Kanwar, Chicago, IL, USA
Nathan Kaufman, Kingston, ON, Canada
Richard Levenson, Woburn, MA, USA
William Lewis, Atlanta, GA, USA
Megan S. Lim, Ann Arbor, MI, USA
Mark Lingen, Chicago, IL, USA
Michael P. Lisanti, Philadelphia, PA, USA
Chen Liu, Gainesville, FL, USA
Virginia A. LiVolsi, Philadelphia, PA, USA
Ricardo V. Lloyd, Rochester, MN, USA
Nicholas W. Lukacs, Ann Arbor, MI, USA
Calum MacAulay, Vancouver, BC, Canada
R. John MacLeod, Kingston, ON, Canada
Declan McCole, San Diego, CA, USA
Bruce McManus, Vancouver, BC, Canada
Didier Merlin, Atlanta, GA, USA
George K. Michalopoulos, Pittsburgh, PA, USA
Kohei Miyazono, Tokyo, Japan
Anthony Montag, Chicago, IL, USA
Laurence Morel, Gainesville, FL, USA
Christopher Moskaluk, Charlottesville, VA, USA
Ivan Moskowitz, Chicago, IL, USA
George F. Murphy, Boston, MA, USA
Toru Nakano, Osaka, Japan
Roberto F. Nicosia, Seattle, WA, USA
Amy Noffsinger, Chicago, IL, USA
Marco Novelli, London, UK
Peter Polverini, Ann Arbor, MI, USA
Michael Prystowsky, Bronx, NY, USA
Janardan K. Reddy, Chicago, IL, USA
Jorge Reis-Filho, London, UK
David L. Rimm, New Haven, CT, USA
Tania Roskams, Flanders, Belgium
Emanuel Rubin, Philadelphia, PA, USA
Shizuya Saika, Wakayama, Japan
Le Shen, Chicago, IL, USA
Fred G. Silva, Augusta, GA, USA
Neena Singh, Cleveland, OH, USA
Mark Sobel, Bethesda, MD, USA
Masahide Takahashi, Nagoya, Japan
Naohiro Terada, Gainesville, FL, USA
Jerrold Turner, Chicago, IL, USA
Paul J. Van Diest, Utrecht, Netherlands
F. Stephen Vogel, Winston-Salem, NC, USA
Lawrence M. Weiss, Duarte, CA, USA
Wendy Wells, Lebanon, NH, USA
Anthony Yachnis, Gainesville, FL