ABOUT THE JOURNAL

Aims and scope of journal

Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology (USCAP) and edited by a board appointed by the Council of the Academy. Laboratory Investigation offers prompt publication of high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease. Both human and experimental studies are welcome. Particular emphasis is given to original research exploring the pathobiology of disease, including insights gained into the structural and molecular pathogenesis of disease, and the biological basis for morphologic manifestations of disease. Laboratory Investigation also constitutes a forum for translation of basic research findings into the progress of diagnosis and assessment of human disease, by means of any laboratory diagnostic methodology. Consideration is given to novel technical advances in the diagnosis of human disease or in the investigation of human or experimental disease. Laboratory Investigation also publishes occasional concise Minireviews and comprehensive Biology of Disease articles.

The journal features the following types of papers:

• Editorial
• Inside Lab Invest
• Pathobiology in Focus
• Perspective
• Letter to the Editor
• Minireview
• Research Articles
• Technical Reports

Impact Factor

Impact Factor: 4.479*

Rank:
5/66 in Pathology
13/81 in Medicine, Research & Experimental

*2007 Journal Citation Report (Thomson Reuters, 2008)

Abstracted/indexed in

Index Medicus
Current Contents (Life Sciences, Science Citation Index, Research Alert, ISI/BioMed)
Excerpta Medica
Biosciences Information Service
Reference Update/Research Information Services

ISSN and eISSN

The international standard serial number (ISSN) for Laboratory Investigation is 0023-6837 and the electronic international standard serial number (eISSN) is 1530-0307.

Editors

Editor-in-Chief

James M. Crawford MD, PhD, is Professor and Chair of Pathology at the University of Florida College of Medicine. He graduated from Duke University School of Medicine, Durham, NC, in 1983, and trained in Anatomic Pathology and Gastrointestinal/Liver Pathology at Brigham and Women's Hospital, Boston MA. After nine years on faculty at Harvard Medical School, he moved to Yale University, New Haven, CT, to be Director of Gastrointestinal Pathology. In 1999, he came to the University of Florida. He is certified in Anatomic Pathology by the American Board of Pathology and has been an USCAP member since 1990. He has authored 140 publications and book contributions and authored or edited 3 books. He served as an executive editor (associate editor) of Laboratory Investigation while at Yale (1997-1998), and has also been associate editor for Hepatology (1997-2001). He is an authority in hepatic pathology, the pathophysiology of bile formation, and hepatic development and microanatomy.

Senior Associate Editors

Anthony T. Yachnis, MD, is an Associate Professor of Pathology at the University of Florida College of Medicine and Chief of Neuropathology. He graduated from George Washington University School of Medicine in 1986 and completed residency and fellowship training in Anatomic Pathology and Neuropathology at the University of Pennsylvania between 1986 and 1991. He subsequently received specialized training in Pediatric Neuropathology at Children's Hospital of Philadelphia. Dr. Yachnis is certified in Anatomic Pathology and Neuropathology by the American Board of Pathology and has been an USCAP member since 1986. He has authored over 80 publications and has won national and local awards for research and teaching. He is a member of the Arthur Purdy Stout Society of Surgical Pathologists. He is an authority in Neuropathology, especially in Neurooncology and Pediatric Neuropathology.

Jerrold R. Turner, MD, PhD, is an Associate Professor of Pathology at The University of Chicago, where he is also Associate Director of the Pathology Residency Program. He graduated from Case Western Reserve University School of Medicine, Cleveland, OH, in 1991 and trained in Anatomic Pathology, Surgical Pathology, and Gastrointestinal/Liver Pathology at Brigham and Women's Hospital, Boston MA. He was on the faculty at Harvard Medical School from 1995 to 1996. In 2001 he moved to The University of Chicago. He is certified in Anatomic Pathology by the American Board of Pathology. He has authored over 60 peer-reviewed publications, editorial, reviews, and book chapters and has served on the editorial boards of Laboratory Investigation, the American Journal of Pathology, the American Journal of Physiology - Gastrointestinal and Liver Physiology, and Clinical Gastroenterology and Hepatology. Research in his laboratory is focused on intestinal transport and barrier function. This includes specific emphasis on cytoskeletal regulation of intercellular junctions in normal physiology and inflammatory disease.

Associate Editors

Raul C. Braylan, MD, is Professor of Pathology at the University of Florida College of Medicine and Chief of Hematopathology, holding the Whisenant Endowed Chair for Experimental Pathology. He earned his MD from Buenos Aires Medical School in Buenos Aires, Argentina in 1960, and trained in Pathology at Mount Sinai Hospital, Chicago, IL, Albert Einstein College of Medicine, Bronx, NY and Memorial Hospital for Cancer/Sloan Kettering Institute, New York, NY. Following several years at the National Cancer Institute he joined the faculty at University of Florida in 1977. He is certified in Anatomic Pathology by the American Board of Pathology and has been an USCAP member since 1980. He has authored over 130 original publications and book chapters. He has been a pioneer in the use of flow cytometry for the diagnosis and assessment of hematopoietic malignancies, and is an authority in diagnostic and molecular hematopathology.

Laurence Morel, PhD, is an Associate Professor of Pathology at the University of Florida College of Medicine. She earned her PhD degree in Neurosciences from the University of Aix-Marseille, France in 1983. She trained as a post-doctoral fellow at the CNRS, Marseille, France, at the University of Georgia, and in the Department of Pathology at the University of Florida, where she joined the faculty in 1999. She has authored over 60 peer-reviewed publications and book chapters. Her research interests include genetics and immunopathology of autoimmune diseases, and the genetic analysis of complex traits in rodents.

Naohiro Terada, MD, PhD, is an Associate Professor of Pathology at the University of Florida College of Medicine. He earned his MD from Osaka University, Osaka, Japan in 1981, and received postdoctoral research training in cancer, signal transduction and stem cell at Osaka University and National Jewish Medical and Research Center, Denver CO, culminating in the awarding of his PhD in cell biology. From 1994-1999, he was an Assistant Professor of Pediatrics at the University of Colorado. He joined the faculty at the University of Florida in 2000. He has authored 80 original publications on signal transduction, cell cycle regulation, and stem cell biology. In recent years he has become a leader in the field of stem cell and regenerative medicine.

Managing Editor

Catherine M. Ketcham, PhD, earned her Ph.D. degree in Biochemistry and Molecular Biology from the University of Florida. Her postdoctoral studies were carried out at Washington University in St. Louis School of Medicine, in the Division of Hematology-Oncology. She then spent seven years in the San Diego biotechnology community focusing on manufacturing issues and business development. Subsequently, she spent three years as a research and development scientist in laboratories associated with the University of Florida Interdisciplinary Center for Biotechnology Research and the Sid Martin Biotechnology Development Incubator.

Pathobiology in Focus Editors

Jerrold R. Turner, MD, PhD, is an Associate Professor of Pathology at The University of Chicago, where he is also Associate Director of the Pathology Residency Program. He graduated from Case Western Reserve University School of Medicine, Cleveland, OH, in 1991 and trained in Anatomic Pathology, Surgical Pathology, and Gastrointestinal/Liver Pathology at Brigham and Women's Hospital, Boston MA. He was on the faculty at Harvard Medical School from 1995 to 1996. In 2001 he moved to The University of Chicago. He is certified in Anatomic Pathology by the American Board of Pathology. He has authored over 60 peer-reviewed publications, editorial, reviews, and book chapters and has served on the editorial boards of Laboratory Investigation, the American Journal of Pathology, the American Journal of Physiology - Gastrointestinal and Liver Physiology, and Clinical Gastroenterology and Hepatology. Research in his laboratory is focused on intestinal transport and barrier function. This includes specific emphasis on cytoskeletal regulation of intercellular junctions in normal physiology and inflammatory disease.

Anirban Maitra, MBBS, is an Associate Professor of Pathology, Oncology and Genetic Medicine at the Johns Hopkins University School of Medicine in Baltimore. He graduated from the All India Institute of Medical Sciences in New Delhi, India in 1996, and subsequently completed residency and fellowship training in Anatomic Pathology and Pediatric Pathology at the University of Texas Southwestern Medical Center in Dallas, Texas. Dr. Maitra then moved to Johns Hopkins as a combined research and clinical fellow in Gastrointestinal and Liver Pathology in 2001, and joined the faculty as an Assistant Professor in July 2003. Dr. Maitra has published over 130 peer-reviewed publications and 22 book chapters. He is an associate editor for Current Molecular Medicine, and has received numerous awards for his research studies including the Benjamin Castleman Award from the United States and Canadian Academy of Pathology. Research in Dr. Maitra's laboratory is focused on the identification and preclinical validation of mechanism-based therapies for pancreatic cancer, elucidating altered signaling pathways in human and mouse models of this malignancy, and the development of targeted drug delivery and imaging modalities for pancreas cancer using nanoparticulate platforms. Recent interests include the characterization of genetic and epigenetic alterations in human embryonic and adult stem cells.

Yasodha Natkunam, MD, PhD, is an assistant professor of Pathology at Stanford University School of Medicine, where she is also co-director of the Immunodiagnosis Laboratory and associate director of Hematopathology. She graduated from Mount Sinai School of Medicine in 1995 and trained in Anatomic Pathology with fellowship training in Surgical Pathology, Immunodiagnosis and Hematopathology at Stanford. She has been on the faculty at Stanford University School of Medicine since 2001. She has authored over 50 peer-reviewed publications and reviews, and co-authored a book on bone marrow diagnosis. Research in her laboratory is focused on using tissue microarrays to explore patterns of protein expression, and translating discoveries toward identifying markers to improve diagnosis, prognostic stratification, and management of patients with hematolymphoid neoplasia.

Brian Rubin, MD, PhD, is assistant professor of Pathology at the University of Washington School of Medicine. He graduated from Cornell University Medical School in New York in 1995, and trained in anatomic pathology and soft tissue pathology at Brigham and Women's Hospital, Boston, MA. He has been the director of bone and soft tissue pathology at the University of Washington since July 2000. He is certified in Anatomic Pathology by the American Board of Pathology and has been an USCAP member since 1997. He has authored over 60 peer-reviewed publications, reviews and book chapters. He is interested in genomics and proteomics of bone and soft tissue neoplasms, in establishing cancer models, and in developing targeted therapies for the treatment of cancer.

Mark Rubin, MD, PhD

Michael A Teitell, MD, PhD, is an associate professor of Pathology and Pediatrics at the David Geffen School of Medicine at UCLA, where he is Chief of the Division of Pediatric and Developmental Pathology. He earned M.D. and Ph.D. degrees from the UCLA Medical Scientist Training Program and trained in Anatomic Pathology at Harvard/Brigham and Women's Hospital, in Clinical Pathology at UCSF, and in Pediatric Pathology at Children's Hospital Los Angeles. He is board-certified in Anatomic, Clinical, and Pediatric Pathology by the American Board of Pathology. Dr. Teitell serves on the editorial boards of Clinical Immunology, Current Immunology Reviews, and Nanomedicine. He has authored over 60 peer-reviewed publications, editorials, reviews, and book chapters. His laboratory research centers on signal transduction and epigenetics of immune system development and cancer, as well as developing new approaches to problems in cancer biology using nanoscale methods.

Editorial Board

Clara Abraham, Chicago, IL, USA
Charles Alpers, Seattle, WA, USA
Gianfranco D. Alpini, Temple, TX, USA
Dario Altieri, Worcester, MA, USA
Robert A. Anders, Baltimore, MD, USA
Sylvia L. Asa, Toronto, Canada
Kenneth Bernstein, Atlanta, GA, USA
Daniel Brat, Atlanta, GA, USA
Martha Campbell-Thompson, Gainesville, FL, USA
Michael B. Cohen, Iowa City, IA, USA
Samuel Cohen, Omaha, NE, USA
William B. Coleman, Chapel Hill, NC, USA
Robert Colvin, Boston, MA, USA
Bogdan A. Czerniak, Houston, TX, USA
Ivan Damjanov, Kansas City, KS, USA
Michael B. Dwinell, Milwaukee, WI, USA
Stephen Galli, Stanford, CA, USA
A. Julian Garvin, Winston-Salem, NC, USA
James D. Gorham, Lebanon, NH, USA
Avrum Gotleib, Toronto, Canada
Allen Gown, Seattle, WA, USA
Michael Hart, Madison, WI, USA
Tong-Chuan He, Chicago, IL, USA
William F. Hickey, Lebanon, NH, USA
Peter Howley, Boston, MA, USA
Renato Iozzo, Philadelphia, PA, USA
Elaine Jaffe, Bethesda, MD, USA
J. Charles Jennette, Chapel Hill, SC, USA
Agnes Kane, Providence, RI, USA
Yashpal Kanwar, Chicago, IL, USA
Nathan Kaufman, Kingston, Canada
William Lewis, Atlanta, GA, USA
Megan S. Lim, Ann Arbor, MI, USA
Mark Lingen, Chicago, IL, USA
Chen Liu, Gainesville, FL, USA
Virginia A. LiVolsi, Philadelphia, PA, USA
Paul M. Lizardi, New Haven, CT, USA
Ricardo Lloyd, Rochester, MN, USA
Nicholas W. Lukacs, Ann Arbor, MI, USA
James Madara, Chicago, IL, USA
Bruce McManus, Vancouver, Canada
Stephen Meredith, Chicago, IL, USA
Didier Merlin, Atlanta, GA, USA
George Michalopoulos, Pittsburgh, PA, USA
Paul Mischel, Los Angeles, CA, USA
Kohei Miyazono, Tokyo, Japan
George Murphy, Philadelphia, PA, USA
Toru Nakano, Osaka, Japan
Roberto Nicosia, Seattle, WA, USA
Peter Polverini, Minneapolis, MN, USA
Michael Prystowsky, New York, NY, USA
Giuliano Ramadori, Göttingen, Germany
Janardan Reddy, Chicago, IL, USA
David L. Rimm, New Haven, CT, USA
Tania Roskams, Leuven, Belgium
Emanuel Rubin, Philadelphia, PA, USA
Shizuya Saika, Wakayama, Japan
Gene P. Siegal, Birmingham, AL, USA
Fred Silva, Augusta, GA, USA
Mark Sobel, Bethesda, MD, USA
Michael Sporn, Hanover, NH, USA
Masahide Takahashi, Nagoya, Japan
Clive Taylor, Los Angeles, CA, USA
Paul J. Van Diest, Utrecht, Netherlands
F. Stephen Vogel, Winston-Salem, NC, USA
Ronald Weinstein, Tucson, AZ, USA
Lawrence Weiss, Duarte, CA, USA
X. Joseph Zhou, Dallas, TX, USA