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Pigs and humans share a vast range of characteristics, including heart anatomy, cardiac electrophysiological properties and hemodynamics, which make pigs a well suited model to study cardiovascular diseases. In a new protocol, Schüttler, Tomsits, Bleyer et al. provide a practical guide to set up pig models for heart disease research, including cardiac electrophysiology and arrhythmogenesis studies.
This protocol details the procedures for safe cardiac catheterization in Landrace pigs, basic electrophysiological assessment of conduction properties, induction of atrial fibrillation and development of a myocardial infarction model.