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Volume 50 Issue 5, May 2021

C. elegans to study host-microbe interactions

Caenorhabditis elegans may be a relatively simple organism on its own, but it nevertheless plays host to unique and diverse microbial communities of even small microorganisms. The various tools available to manipulate both the worm and its various microbial residents make C. elegans a valuable biosensor in which to probe the intricacies of host-microbe interactions, which can yield important insight into such relationships in more complex organisms, including humans. The microbiome field has much to learn from the worm as a model.

See Cabreiro et al.

IMAGE: Marina Spence. COVER DESIGN: Marina Spence

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  • Over a year into the pandemic, animal providers have been working to meet changing demand for the animal models needed to study SARS-CoV-2

    • Ellen P. Neff
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  • The SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques, which might outstrip the supply for COVID-19 research and for other biomedical research studies. Baboons, another well-characterized research primate model, should be considered as a promising alternative for COVID-19 disease studies.

    • Michael C. Chang
    • Sheri Hild
    • Franziska Grieder
    Comment
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  • Social isolation can lead to poor mental and physical health. A new study determines that social isolation increases food and nicotine-seeking during abstinence, but that social housing can reverse these effects.

    • Rebecca S. Hofford
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