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Caenorhabditis elegans may be a relatively simple organism on its own, but it nevertheless plays host to unique and diverse microbial communities of even small microorganisms. The various tools available to manipulate both the worm and its various microbial residents make C. elegans a valuable biosensor in which to probe the intricacies of host-microbe interactions, which can yield important insight into such relationships in more complex organisms, including humans. The microbiome field has much to learn from the worm as a model.
The SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques, which might outstrip the supply for COVID-19 research and for other biomedical research studies. Baboons, another well-characterized research primate model, should be considered as a promising alternative for COVID-19 disease studies.
Social isolation can lead to poor mental and physical health. A new study determines that social isolation increases food and nicotine-seeking during abstinence, but that social housing can reverse these effects.
In this perspective, the authors discuss the use of Caenorhabditis elegans as a model system to study host–microbe interactions, highlighting innovative methodologies and key findings from recent studies.