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The micropipette-guided drug administration (MDA) method was originally developed as a less-stressful alternative to oral gavage for delivering drugs to laboratory mice. New research published this month evaluates the MDA approach as a non-invasive alternative to intraperitoneal injections to deliver ligands for DREADD systems, a chemogenetic technique for manipulating neuronal activity in behaving animals.
A look at viral surveillance and how researchers and veterinarians identify what animals may be susceptible to different viruses, including SARS-CoV-2.
In this article, the authors evaluate the suitability and effectiveness of their micropipette-guided drug administration method as an alternative and non-invasive administration strategy for clozapine-N-oxide in chemogenetic studies using designer receptors exclusively activated by designer drugs.