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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Beckwith–Wiedemann syndrome associated with congenital hypothyroidism in a preterm neonate: a case report and literature review

Journal of Perinatology volume 29, pages 455–457 (2009)Cite this article

Abstract

This report describes for the first time the association of Beckwith–Wiedemann syndrome (BWS) and hypothyroidism in a 25 weeks preterm neonate. Antenatal diagnosis of exomphalos in association with postnatal transient hypoglycemia and macroglossia formed the basis of the diagnosis of BWS. Primary hypothyroidism was detected on routine Guthrie card examination. Molecular DNA analysis demonstrated biparental inheritance of chromosome 11p15.5. Dosage analysis of differently methylated region showed evidence of loss of maternal methylation at KvDMR1.

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Authors and Affiliations

  1. Department of Neonatology, Regional Neonatal Intensive Care Unit, St George's Hospital, London, UK

    G I Ramadan & N L Kennea

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  1. G I Ramadan
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  2. N L Kennea
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Correspondence to G I Ramadan.

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Ramadan, G., Kennea, N. Beckwith–Wiedemann syndrome associated with congenital hypothyroidism in a preterm neonate: a case report and literature review. J Perinatol 29, 455–457 (2009). https://doi.org/10.1038/jp.2008.208

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  • DOI: https://doi.org/10.1038/jp.2008.208

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