Abstract
The incidence of glucose-6-phosphate dehydrogenase deficiency in neonates of immigrant mothers in Canada is increasing. Newborn screening programs in Canada do not screen for this disorder. Infants with G-6-PD deficiency may develop jaundice resulting in kernicterus with devastating sequelae. In this case report, we speculate that Clostridium difficile infection may have triggered severe jaundice in G-6-PD-deficient neonates.
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References
Kaplan M, Hammerman C . Glucose-6 phosphate dehydrogenase deficiency: a worldwide potential cause of severe neonatal hyperbilirubinemia. Neo Rev 2000; 1: e32–e38.
Kaplan M, Hammerman C . Glucose-6-phosphate dehydrogenase-deficient neonates: a potential cause for concern in North America. Pediatrics 2000; 106 (6): 1478–1479.
AlOtaibi SF, Blaser S, MacGregor DL . Neurological complications of kernicterus. Can J Neurol Sci 2005; 32 (3): 311–315.
Sgro M, Campbell D, Shah V . Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ 2006; 175 (6): 587–590.
Abdulrazzaq YM, Micallef R, Qureshi M, Dawodu A, Ahmed I, Khidr A et al. Diversity in expression of glucose-6 phosphate dehydrogenase deficiency in females. Clin Genet 1999; 55 (1): 13–19.
Kaplan M, Hammerman C . Severe hemolysis and hyperbilirubinemia due to perinatal napthalene exposure. J Perinatol 2005; 25 (5): 359; author reply 360.
Miller MA, Hyland M, Ofner-Agostini M, Gourdeau M, Ishak M . Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals. Infect Control Hosp Epidemiol 2002; 23 (3): 137–140.
Eckel F, Huber W, Weiss W, Lersch C . Recurrent pseudomembranous colitis as a cause of recurrent severe sepsis. Z Gastroenterol 2002; 40 (4): 255–258.
Rampling A, Warren RE, Bevan PC, Hoggarth CE, Swirsky D, Hayhoe FG . Clostridium difficile in haematological malignancy. J Clin Pathol 1985; 38 (4): 445–451.
Abu-Osba YK, Mallouh AA, Hann RW . Incidence and causes of sepsis in glucose-6-phosphate dehydrogenase-deficient newborn infants. J Pediatr 1989; 114 (5): 748–752.
Krasnopolskaya XD, Shatskaya TL . Distribution of Gd- alleles in some ethnic groups of the USSR. Hum Genet 1987; 75 (3): 258–263.
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Lodha, A., Kamaluddeen, M., Kelly, E. et al. Clostridium difficile infection precipitating hemolysis in glucose-6-phosphate dehydrogenase-deficient preterm twins causing severe neonatal jaundice. J Perinatol 28, 77–78 (2008). https://doi.org/10.1038/sj.jp.7211853
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DOI: https://doi.org/10.1038/sj.jp.7211853