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Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio

Journal of Perinatology volume 27, pages 272–277 (2007)Cite this article

Abstract

Objective:

Evaluate the value of random urinary protein-creatinine (PrCr) and calcium-creatinine (CaCr) ratios to predict 24-h proteinuria in hypertensive pregnancies.

Study Design:

Spot urine samples were collected before routine 24-h urine collections from consecutive pregnant women with hypertension (n=83). Reliability of spot urinary PrCr and CaCr to detect significant proteinuria (⩾300 mg/day) using 24-h urine protein as ‘gold-standard’ was assessed by receiver-operating characteristic (ROC) curve.

Results:

Fifty-one patients (61.4%) had significant proteinuria (45 pre-eclampsia, 5 superimposed pre-eclampsia, 1 renal hypertension). Area under ROC curve to predict proteinuria was 0.82 (95% confidence interval (CI) 0.73 to 0.92, P<0.001) for PrCr and 0.55 (95% CI 0.43 to 0.68, P=0.2) for CaCr. A cutoff value of >0.19 for PrCr best predicted significant proteinuria with sensitivity, specificity, positive and negative predictive values and likelihood ratios (positive and negative), respectively, of 80.4, 68.8, 80.4, 68.8%, 2.57 and 3.51.

Conclusion:

Spot urinary PrCr predicts total urinary protein excretion in hypertensive pregnancies.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, United Arab Emirates University, Al-Ain, UAE

    D E E Rizk

  2. Department of Pathology, United Arab Emirates University, Al-Ain, UAE

    M M Agarwal

  3. Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE

    J Y Pathan & E N Obineche

Authors
  1. D E E Rizk
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  2. M M Agarwal
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  3. J Y Pathan
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  4. E N Obineche
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Correspondence to D E E Rizk.

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Rizk, D., Agarwal, M., Pathan, J. et al. Predicting proteinuria in hypertensive pregnancies with urinary protein-creatinine or calcium-creatinine ratio. J Perinatol 27, 272–277 (2007). https://doi.org/10.1038/sj.jp.7211689

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