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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Tricuspid Valve Thrombus and Pulmonary Embolus in an Infant with Homozygous Thermolabile Methylenetetrahydrofolate Reductase and Heterozygous Prothrombin G20210A Variant

Journal of Perinatology volume 23, pages 513–515 (2003)Cite this article

Abstract

We describe an unusual and interesting case of a full-term infant presenting at 7 days of life with HSV pneumonitis and a tricuspid valve thrombus ultimately requiring extracorporeal membrane oxygenation. The infant subsequently developed a pulmonary embolus. The infant was found to be heterozygous for the prothrombin G20210A mutation and homozygous for the methylenetetrahydrofolate reductase C667T mutation. The patient was treated with low molecular weight heparin for a total of 3 months and has not had a recurrent thrombosis. This case illustrates that a combination of congenital and acquired thrombophilic risk factors can contribute to a significant thrombotic event.

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Authors and Affiliations

  1. Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA

    Courtney D Thornburg MD, Keri A Lattimore MD & Steven W Pipe MD

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  1. Courtney D Thornburg MD
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  2. Keri A Lattimore MD
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  3. Steven W Pipe MD
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Thornburg, C., Lattimore, K. & Pipe, S. Tricuspid Valve Thrombus and Pulmonary Embolus in an Infant with Homozygous Thermolabile Methylenetetrahydrofolate Reductase and Heterozygous Prothrombin G20210A Variant. J Perinatol 23, 513–515 (2003). https://doi.org/10.1038/sj.jp.7210951

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