Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Inhaled Nitric Oxide (iNO) Delivery with High-frequency Jet Ventilation (HFJV)

Journal of Perinatology volume 23, pages 387–391 (2003)Cite this article

Abstract

OBJECTIVE: To determine if nitric oxide (NO) therapy can be reliably administered during high-frequency jet ventilation (HFJV) using the INOvent delivery system.

STUDY DESIGN: NO concentrations were measured just proximal to the endotracheal (ET) tube and at the distal tip of the ET tube during a bench evaluation. Measurements were taken over a wide range of airway pressure settings and NO concentrations with both high- and low- resistance lung models. Percent changes in set versus proximal and proximal versus distal iNO concentrations were tabulated.

RESULTS: Differences between proximal and distal NO concentrations were 10% or less. In the therapeutic range of up to 20 p.p.m., differences in concentration were 1 p.p.m. or less. There was no consistent effect on NO concentration when airway resistance was increased by 500%.

CONCLUSION: Nitric oxide therapy can be reliably administered during HFJV with the INOvent delivery system when NO is injected exclusively via the HFJV circuit.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. The Neonatal Inhaled Nitric Oxide Study Group (NINOS). Inhaled nitric oxide in full-term and nearly full term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597–604.

  2. Clark RK, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med 2000;342:469–474.

    Article  CAS  Google Scholar 

  3. Roberts Jr. JD, Fineman JR, Morin III FC, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med 1997;336:605–610.

    Article  CAS  Google Scholar 

  4. Kinsella JP, Abman SH . Inhaled nitric oxide and high frequency oscillatory ventilation in persistent pulmonary hypertension of the newborn. Eur J Pediatr 1998;157:S28–30.

    Article  CAS  Google Scholar 

  5. Kim JP, Abman SH . High frequency oscillatory ventilation augments the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Nitric Oxide Study Group. Chest 1998;114:100S.

    Google Scholar 

  6. Hoehn T, Krause M, Hentschel R . High-frequency oscillatory ventilation augments the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Eur Respir J 1998;11:234–238.

    Article  CAS  Google Scholar 

  7. Kinsella JP, Truog WE, Walsh WF, et al. Randomized, multicenter trial of inhaled nitric oxide and high- frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 1997;131:55–62.

    Article  CAS  Google Scholar 

  8. Day RW, Lynch JM, White KS, Ward RM . Acute response to inhaled nitric oxide in newborns with respiratory failure and pulmonary hypertension. Pediatrics 1996;98:698–705.

    CAS  PubMed  Google Scholar 

  9. Keszler M, Donn SM, Bucciarelli RL, et al. Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema. J Pediatr 1991;119:85–93.

    Article  CAS  Google Scholar 

  10. Mortimer TW, Math MC, Fajardo CA . Inhaled nitric oxide delivery with high-frequency jet ventilation: a bench study. Resp Care 1996;41 (10):895–902.

    Google Scholar 

  11. Keszler M, Modanlou HD, Brudno DS, et al. Multicenter controlled clinical trial of high-frequency jet ventilation in preterm infants with uncomplicated respiratory distress syndrome. Pediatrics 1997;100:593–599.

    Article  CAS  Google Scholar 

  12. Datex-Ohmeda. INOvent application update #10. Madison, WI: Datex-Ohmeda, Inc.; (Revised November 2000).

Download references

Author information

Authors and Affiliations

  1. Bunnell Incorporated, Salt Lake City, UT, USA

    David R Platt MS, RRT

  2. Presbyterian/St. Luke's Hospital, Denver, CO, USA

    Doug Swanton RRT

  3. Sutter Memorial Hospital, Sacramento, CA, USA

    David Blackney RRT

Authors
  1. David R Platt MS, RRT
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Doug Swanton RRT
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Blackney RRT
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was funded by Bunnell Incorporated

Rights and permissions

Reprints and permissions

About this article

Cite this article

Platt, D., Swanton, D. & Blackney, D. Inhaled Nitric Oxide (iNO) Delivery with High-frequency Jet Ventilation (HFJV). J Perinatol 23, 387–391 (2003). https://doi.org/10.1038/sj.jp.7210939

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7210939

This article is cited by

Search

Advanced search

Quick links