Journal of Perinatology
SEARCH     advanced search my account e-alerts subscribe register
Journal home
Advance online publication
Current issue
Archive
Press releases
For authors
For referees
Contact editorial office
About the journal
For librarians
Subscribe
Advertising
naturereprints
Contact Springer Nature
Customer services
Site features
NPG Subject areas
Access material from all our publications in your subject area:
Biotechnology Biotechnology
Cancer Cancer
Chemistry Chemistry
Dentistry Dentistry
Development Development
Drug Discovery Drug Discovery
Earth Sciences Earth Sciences
Evolution & Ecology Evolution & Ecology
Genetics Genetics
Immunology Immunology
Materials Materials Science
Medical Research Medical Research
Microbiology Microbiology
Molecular Cell Biology Molecular Cell Biology
Neuroscience Neuroscience
Pharmacology Pharmacology
Physics Physics
Browse all publications
 

September 2002, Volume 22, Number 6, Pages 461-466

Table of contents    Previous  Abstract  Next   Full text  PDF

Original Article

Crossover Trial Comparing Pressure Support With Synchronized Intermittent Mandatory Ventilation†

Steven L Olsen MD, Donald W Thibeault MD and William E Truog MD

Department of Pediatrics, Section of Neonatology, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

Correspondence to: William E. Truog, MD, Section of Neonatology, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA


This work was presented at Pediatric Academic Societies Meeting, Baltimore, MD, 2001.

Abstract

OBJECTIVE: To compare pressure support ventilation (PSV) with volume guarantee (VG) to synchronized intermittent mandatory ventilation (SIMV) in infants with respiratory distress syndrome (RDS).

STUDY DESIGN: A randomized, crossover study design was used. We enrolled 14 infants [BW (mean±SD) 2.5±0.7 kg, GA 34±2 weeks, age 49±26 hours]. Subjects received 4 hours of each mode of ventilation, with the first mode selected randomly. End expiratory volume (EEV) was measured during both ventilatory modes.

RESULTS: Minute ventilation was greater with PSV+VG than with SIMV (p=0.012). This occurred despite no difference in paCO2. Mean airway pressure was higher during PSV+VG (p=0.023). There was no difference in the arterial/alveolar oxygen tension (a/A) ratio or in the specific dynamic compliance (sCdyn).

CONCLUSION: Because of an increase in VE with PSV+VG, and no difference in the a/A ratio or sCdyn, we do not recommend the routine use of PSV+VG for this population. Journal of Perinatology (2002) 22, 461-466 doi:10.1038/sj.jp.7210772

September 2002, Volume 22, Number 6, Pages 461-466

Table of contents    Previous  Abstract  Next   Full text  PDF