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Nitric oxide and cell adhesion molecules in essential hypertension: a case control study

Journal of Human Hypertension volume 20, pages 537–539 (2006)Cite this article

To elucidate the significance of nitric oxide (NO), E-selectin and sVCAM-1 in essential hypertension, we determined the levels of these molecules in healthy volunteers and patients with essential hypertension, evaluated their correlations and association with the disease. This case–control study, the first of its kind from India, revealed significant association of low levels of NO and high levels of E-selectin and sVCAM-1 with the disease and negative correlations of NO with the cell adhesion molecules and diastolic blood pressure. An impairment of the normal homeostasis of these molecules is envisaged to play a significant role in the pathophysiology and hence, the risk of essential hypertension.

A total of 65 patients (age 49.45±7.4 years, 43 male, 22 female, systolic blood pressure=145.5±14.05 mm Hg, diastolic blood pressure=93.6±8.09 mm Hg) diagnosed for essential hypertension at the Department of Cardiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India and 53 normal healthy volunteers (age 47.13±4.56 years, 36 male, 17 female, systolic blood pressure=120±3.47 mm Hg, diastolic blood pressure=80.49±2.53 mm Hg, and no history of cardiovascular disorders) were recruited for the study. Individuals who smoked heavily were grouped under smokers. Out of 53 controls, 10 were smokers. Out of 65 patients, 25 were smokers. Volunteers with history of recent medication, drugs and alcohol abuse, major infection, secondary forms of hypertension, diabetes mellitus, renal failure and women on oral contraceptives were excluded from the study. Approval of the ethical committee of AIIMS, New Delhi was obtained, and its guidelines were followed.

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Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

    K Srivastava, S Das & N Das

  2. Department of Cardiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

    R Narang

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  1. K Srivastava
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  4. N Das
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Correspondence to N Das.

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Srivastava, K., Narang, R., Das, S. et al. Nitric oxide and cell adhesion molecules in essential hypertension: a case control study. J Hum Hypertens 20, 537–539 (2006). https://doi.org/10.1038/sj.jhh.1002034

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