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Effects of low-dose aspirin on blood pressure and endothelial function of treated hypertensive hypercholesterolaemic subjects

Journal of Human Hypertension volume 19, pages 667–673 (2005)Cite this article

Abstract

The main objective of this study was to assess whether aspirin 100 mg QD can improve blood pressure (BP) control and endothelial function in subjects with arterial hypertension (AH) and hypercholesterolaemia. In total, 21 patients of both sexes (52.1±11.5 years) with treated AH and hypercholesterolaemia on antihypertensive and statin therapy were included in the treatment group. In the control group, 20 matched patients of both sexes (51.3±12.7 years), but without statin therapy, were recruited. Treatment group subjects received aspirin (100 mg QD) for a duration of 12 weeks at randomization (Treatment phase-1), followed by single blind matching placebo for 12 weeks (Placebo phase) and then again received aspirin (100 mg QD) for an additional 12 weeks (Treatment phase-2). The control group participated in Treatment phase-1, but did not continue Placebo phase and Treatment phase-2. At randomization and at the end of each study phase, mean 24-h systolic BP (SBP) and diastolic BP (DBP) were assessed by 24-h ambulatory blood pressure monitoring (ABPM) and endothelium-dependent (flow mediated, FMD) and -independent (nitroglycerin induced, NTG) vasodilatations of brachial artery were measured using high-resolution ultrasound. In Treatment phase-1, reduction of SBP and DBP (ΔSBP 5.7±2.6 mmHg, P=0.008; ΔDBP 3.8±1.7 mmHg, P=0.014) and improvement of FMD (4.1±0.6%, P=0.019), in Placebo phase an elevation of SBP and DBP (ΔSBP −6.2±2.9 mmHg, P=0.002; ΔDBP −4.2±1.9 mmHg, P=0.031) and worsening of FMD (−3.8±0.9%, P=0.027), and in Treatment phase-2 reduction of SBP and DBP (ΔSBP 4.9±2.3 mmHg, P=0.005; ΔDBP 4.1±1.3 mmHg, P=0.024) and improvement of FMD (4.5±1.3%, P=0.009) were observed in the treatment Group but not in the control group. Addition of low-dose aspirin to antihypertensive medications and statins in hypertensive and hypercholesterolaemic subjects can reduce both SBP and DBP by improvement of endothelial function.

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References

  1. Hansson L et al for the HOT Study Group. Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755–1762.

    CAS  Google Scholar 

  2. Medical Research Council's General Practice Research Framework. Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet 1998; 351: 233–241.

  3. Collaborative Group of the Primary Prevention Project (PPP). Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001; 357: 89–95.

  4. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71–86.

  5. Johnson AG, Nguyen TV, Day RO . Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann Intern Med 1994; 121: 289–300.

    CAS  PubMed  Google Scholar 

  6. Magagna A et al. Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients. Blood Press 1994; 3: 236–241.

    CAS  PubMed  Google Scholar 

  7. Hermida RC et al. Influence of aspirin usage on blood pressure: dose and administration-time dependencies. Chronobiol Int 1997; 14: 619–637.

    CAS  PubMed  Google Scholar 

  8. Avanzini F et al on behalf of the Collaborative Group of the Primary Prevention Project (PPP)-Hypertension study. Effects of low-dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients. Am J Hypertens 2000; 13: 611–616.

    CAS  PubMed  Google Scholar 

  9. Nawarskas JJ, Townsend RR, Cirigliano MD, Spinler SA . Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan. Am J Hypertens 1999; 12: 784–789.

    CAS  PubMed  Google Scholar 

  10. Pope JE, Anderson JJ, Felson DT . A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch Intern Med 1993; 153: 477–484.

    CAS  PubMed  Google Scholar 

  11. Gurwitz JH et al. Initiation of antihypertensive treatment during nonsteroidal anti-inflammatory drug therapy. JAMA 1994; 272: 781–786.

    CAS  PubMed  Google Scholar 

  12. Johnson AG . NSAIDs and increased blood pressure. What is the clinical significance? Drug Safety 1997; 17: 277–289.

    CAS  PubMed  Google Scholar 

  13. Medical Research Council's General Practice Research Framework. Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet 1998; 351: 233–241.

  14. Collaborative Group of the Primary Prevention Project (PPP). Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001; 357: 89–95.

  15. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71–86.

  16. Corretti MC et al International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 1082.

    Google Scholar 

  17. Farmer JA . Pleotropic effects of statins. Curr Atheroscler Rep 2000; 2: 208–217.

    CAS  PubMed  Google Scholar 

  18. O'Driscoll G, Green D, Taylor RR . Simvastatin, an HMG-coenzyme A reduclase inhibitor, improves endothelial function within I month. Circulation 1997; 95: 1126–1131.

    CAS  PubMed  Google Scholar 

  19. Fossum E et al. The interaction between aspirin and losartan on cardiovascular morbidity and mortality in patients with hypertension and left ventricular hypertrophy. A losartan intervention for endpoint reduction (LIFE) substudy. J Hypertens 2003; 21(Suppl 4): S118. Abstract 6A.1.

    Google Scholar 

  20. Fisman EZ, Grossman E, Motro M, Tenenbaum A . Clinical evidence of dose-dependent interaction between aspirin and angiotensin-converting enzyme inhibitors. J Hum Hypertens 2002; 16: 379–383.

    CAS  PubMed  Google Scholar 

  21. Zanchetti A et al. Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy. J Hypertens 2002; 20: 1015–1022.

    CAS  PubMed  Google Scholar 

  22. Oosterga M et al. Effects of aspirin on angiotensin-converting enzyme inhibition and left ventricular dilation one year after acute myocardial infarction. Am J Cardiol 1998; 81: 1178–1181.

    CAS  PubMed  Google Scholar 

  23. Nawarskas JJ, Spinler SA . Does aspirin interfere with the therapeutic efficacy of angiotensin-converting enzyme inhibitors in hypertension or congestive heart failure? Pharmacotherapy 1998; 18: 1041–1052.

    CAS  PubMed  Google Scholar 

  24. Morgan TO, Anderson A, Bertram D . Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. Am J Hypertens 2000; 13: 1161–1167.

    CAS  PubMed  Google Scholar 

  25. Pope JE, Anderson JJ, Felson DT . A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch Intern Med 1993; 153: 477–484.

    CAS  PubMed  Google Scholar 

  26. Johnson AG, Nguyen TV, Day RO . Do nonsteroidal anti-inflammatory drugs affect blood pressure? Ann Intern Med 1994; 121: 289–300.

    CAS  PubMed  Google Scholar 

  27. Conlin PR et al. Angiotensin II antagonists for hypertension: are there differences in efficacy? Am J Hypertens 2000; 13: 418–426.

    CAS  PubMed  Google Scholar 

  28. Noon JP, Walker BR, Hand MF, Webb DJ . Impairment of forearm vasodilatation to acetylcholine in hypercholesterolemia is reversed by aspirin. Cardiovasc Res 1998; 38: 480–484.

    CAS  PubMed  Google Scholar 

  29. Husain S et al. Aspirin improves endothelial dysfunction in atherosclerosis. Circulation 1998; 97: 716–720.

    CAS  PubMed  Google Scholar 

  30. Campia U et al. Role of cyclooxygenase products in the regulation of vascular tone and in the endothelial vasodilator function of normal, hypertensive, and hypercholesterolemic humans. Am J Cardiol 2002; 89: 286–290.

    CAS  PubMed  Google Scholar 

  31. Chenevard R et al. Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 2003; 28(107): 405–409.

    Google Scholar 

  32. Bulut D et al. Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension. J Hypertens 2003; 21(9): 1663–1667.

    CAS  PubMed  Google Scholar 

  33. Taubert D et al. Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action. Br J Pharmacol 2004; 143(1): 159–165.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Madajka M, Korda M, White J, Malinski T . Effect of aspirin on constitutive nitric oxide synthase and the biovailability of NO. Thromb Res 2003; 110(5–6): 317–321.

    CAS  PubMed  Google Scholar 

  35. Libby P, Ridker PM, Maseri A . Inflammation and atherosclerosis. Circulation 2002; 105: 1135–1143.

    CAS  Google Scholar 

  36. Belton O et al. Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. Circulation 2000; 102: 840–845.

    CAS  Google Scholar 

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Authors and Affiliations

  1. WHO Collaborative Center for Prevention of CVD, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel

    E Magen, J R Viskoper, J Mishal, R Priluk & D London

  2. Non invasive Cardiac Laboratory, Massachusets General Hospital, Boston, MA, USA

    C Yosefy

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  1. E Magen
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Correspondence to J R Viskoper.

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Magen, E., Viskoper, J., Mishal, J. et al. Effects of low-dose aspirin on blood pressure and endothelial function of treated hypertensive hypercholesterolaemic subjects. J Hum Hypertens 19, 667–673 (2005). https://doi.org/10.1038/sj.jhh.1001910

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