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NSAID use and BP in treated hypertensives: a retrospective controlled observational study

Journal of Human Hypertension volume 19, pages 445–450 (2005)Cite this article

Abstract

The objective of this study was to investigate the association between NSAID use and blood pressure (BP) among a sample of treated hypertensive patients. A controlled observational study was designed in UK primary care setting. Patients with diagnosed hypertension and currently being prescribed antihypertensive medication registered with four general practices, comparing patients also prescribed NSAIDs (exposed) to those not prescribed NSAIDs (unexposed). Majority of the patients were elderly. Systolic and diastolic pressure were the outcome measures. Data were collected for 184 NSAID users and 762 nonusers with a mean age of 68 years. There was no difference in either systolic (adjusted difference 1.9 mmHg, 95% CI −0.7 to 4.5, P=0.15) or diastolic (adjusted difference 1.0 mmHg, 95% CI −0.3 to 2.3, P=0.15) blood pressure. There was no evidence of any interactions according to categories of age, sex, or number of antihypertensive drugs prescribed. Among NSAID users, there was no evidence of any differences in blood pressure according to NSAID type or dose. In conclusion we found no evidence for an association between NSAID usage and BP control in known hypertensive patients receiving antihypertensive medication in primary care. The reported association between NSAID use and BP control appears much less substantial than has been previously suggested.

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Authors and Affiliations

  1. Department of Geriatric and General Medicine, South-West England Rotation (Bristol Royal Infirmary, Royal Devon & Exeter, and Frenchay Hospitals), UK

    R Sheridan

  2. Division of Primary Health Care, University of Bristol, Bristol, UK

    A A Montgomery

  3. Department of Primary Care Medicine, Tayside Centre for General Practice, University of Dundee, Dundee, UK

    T Fahey

Authors
  1. R Sheridan
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  2. A A Montgomery
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  3. T Fahey
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Correspondence to R Sheridan.

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There are no funding issues or conflicts of interest for any of the authors.

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Sheridan, R., Montgomery, A. & Fahey, T. NSAID use and BP in treated hypertensives: a retrospective controlled observational study. J Hum Hypertens 19, 445–450 (2005). https://doi.org/10.1038/sj.jhh.1001839

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  • DOI: https://doi.org/10.1038/sj.jhh.1001839

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