Original Article

The Journal of Antibiotics (2006) 59, 495–499; doi:10.1038/ja.2006.69

Cylindrocyclin A, a New Cytotoxic Cyclopeptide from Cylindrocarpon sp.

Daniela Weber1, Gilda Erosa2, Olov Sterner2 and Timm Anke1

  1. 1Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany
  2. 2Division of Organic Chemistry, Lund University, P.O.B. 124, S-22100 Lund, Sweden

Correspondence: T. Anke, Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany. E-mail: timm.anke@ibwf.uni-kl.de

Received 30 May 2006; Accepted 11 August 2006.

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Abstract

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 muM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.

Keywords:

new metabolite, cyclopeptide, cytotoxic, cylindrocarpon

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