Abstract
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 μM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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Weber, D., Erosa, G., Sterner, O. et al. Cylindrocyclin A, a New Cytotoxic Cyclopeptide from Cylindrocarpon sp.. J Antibiot 59, 495–499 (2006). https://doi.org/10.1038/ja.2006.69
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DOI: https://doi.org/10.1038/ja.2006.69
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