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Role of 5′AMP-activated protein kinase in skeletal muscle

International Journal of Obesity volume 32, pages S13–S17 (2008)Cite this article

Abstract

5′AMP-activated protein kinase (AMPK) is recognized as an important intracellular energy sensor, shutting down energy-consuming processes and turning on energy-generating processes. Discovery of target proteins of AMPK has dramatically increased in the past 10 years. Historically, AMPK was first shown to regulate fatty acid and cholesterol synthesis, but is now hypothesized to take part in the regulation of energy/fuel balance not only at the cellular level but also at the level of the whole organism. In this brief review we will discuss some of the roles of AMPK in skeletal muscle.

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Acknowledgements

This review was supported by funds from the Commission of the European Communities (contract no. LSHM-CT-2004-005272 EXGENESIS and contract no. LSHM-CT-2004-512013 EUGENE2), the Danish Medical Research Council, the Novo Nordisk Foundation, the Danish Diabetes Association and the Copenhagen Muscle Research Centre. JFPW was supported by a Hallas Møller fellowship from the Novo Nordisk Foundation.

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  1. Molecular Physiology Group, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark

    J T Treebak & J F P Wojtaszewski

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Correspondence to J F P Wojtaszewski.

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Treebak, J., Wojtaszewski, J. Role of 5′AMP-activated protein kinase in skeletal muscle. Int J Obes 32 (Suppl 4), S13–S17 (2008). https://doi.org/10.1038/ijo.2008.117

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