Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats)

International Journal of Obesity volume 25, pages 1281–1285 (2001)Cite this article

Abstract

OBJECTIVE: To investigate whether beacon administration affects substrate utilisation, physical activity levels or energy expenditure in Psammomys obesus.

DESIGN: Pairs of age- and sex-matched Psammomys obesus were randomly assigned to either beacon-treated (15 μg/day for 7 days (i.c.v.)) or control (i.c.v. saline) groups.

MEASUREMENTS: Indirect calorimetry on day 0 and day 7 to measure oxygen consumption and carbon dioxide production, which were used to calculate fat oxidation, carbohydrate oxidation and total energy expenditure. Physical activity in the calorimeter was measured using an infrared beam system. Food intake and body weight were measured daily.

RESULTS: The administration of beacon significantly increased body weight compared to saline-treated control animals. This body weight gain was primarily due to increased body fat content. Average daily food intake tended to be higher in beacon-treated Psammomys obesus, but no effect of beacon administration on substrate oxidation, activity or energy expenditure was detected.

CONCLUSION: The effects of beacon on body weight are due to increased food intake, with no detectable effect on nutrient partitioning, physical activity or energy expenditure.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Collier GR, McMillan JS, Windmill K, Walder K, Tenne-Brown J, de Silva A, Trevaskis J, Jones S, Morton GJ, Lee S, Augert G, Civitarese A, Zimmet PZ . Beacon. A novel gene involved in the regulation of energy balance Diabetes 2000 49: 1766–1771.

    Article  CAS  Google Scholar 

  2. Shafrir E, Gutman A . Psammomys obesus of the Jerusalem colony: A model for nutritionally induced, non-insulin-dependent diabetes J Basic Clin Phys Pharm 1993 4: 83–99.

    CAS  Google Scholar 

  3. Walder KR, Fahey RP, Morton GJ, Zimmet PZ, Collier GR . Characterization of obesity phenotypes in Psammomys obesus (Israeli Sand Rats) Int J Exp Diabetes Res 2000 1: 177–184.

    Article  CAS  Google Scholar 

  4. Barnett M, Collier GR, Collier FM, Zimmet P, O'Dea K . A cross-sectional and short-term longitudinal characterization of NIDDM in Psammomys obesus Diabetologia 1994 37: 671–676.

    Article  CAS  Google Scholar 

  5. Ziv E, Kalman R . Psammomys obesus: primary insulin resistance leading to nutritionally induced type 2 diabetes. In: Sima AAF, Shafrir E (eds). Animal models of diabetes: a primer Harwood Academic: New York 2000 327–342.

    Google Scholar 

  6. Weir JB . New methods for calculating metabolic rate with special reference to protein metabolism. 1949, (Classical article) Nutrition 1990 6: 213–221.

    CAS  PubMed  Google Scholar 

  7. Frayn KN . Calculation of substrate oxidation rates in vivo from gaseous exchange J Appl Physiol 1983 55: 628–634.

    Article  CAS  Google Scholar 

  8. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F . Effects of the obese gene product on body weight regulation in ob/ob mice Science 1995 269: 540–543.

    Article  CAS  Google Scholar 

  9. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM . Weight-reducing effects of the plasma protein encoded by the obese gene Science 1995 269: 543–546.

    Article  CAS  Google Scholar 

  10. Clark JT, Kalra PS, Crowley WR, Kalra SP . Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats Endocrinology 1984 115: 427–429.

    Article  CAS  Google Scholar 

  11. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF . Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity Peptides 1986 7: 1189–1192.

    Article  CAS  Google Scholar 

  12. Egawa M, Yoshimoto H, Bray GA . Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue Neuroscience 1990 34: 771–775.

    Article  CAS  Google Scholar 

  13. Billington CJ, Briggs JE, Grace M, Levine AS . Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism Am J Physiol 1991 260: R321–R327.

    CAS  PubMed  Google Scholar 

  14. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R, Maratos-Flier E . A role for melanin-concentrating hormone in the central regulation of feeding behaviour Nature 1996 380: 243–246.

    Article  CAS  Google Scholar 

  15. Rossi M, Choi S, O'Shea D, Miyoshi T, Ghatei M, Bloom S . Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight Endocrinology 1997 138: 351–355.

    Article  CAS  Google Scholar 

  16. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E . Mice lacking melanin-concentrating hormone are hypophagic and lean Nature 1998 396: 670–674.

    Article  CAS  Google Scholar 

  17. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M . Orexins and orexin receptors: A family of hypothalamic neuropeptides and G-coupled receptors that regulate feeding behaviour Cell 1998 92: 696–704.

    Google Scholar 

  18. Lubkin M, Stricker-Krongrad A . Independent feeding and metabolic actions of orexins in mice Biochem Biophys Res Commun 1998 253: 241–245.

    Article  CAS  Google Scholar 

  19. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M . Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation Cell 1999 98: 437–451.

    Article  CAS  Google Scholar 

  20. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E . Hypocretin (orexin) deficiency in human narcolepsy Lancet 2000 355: 39–40.

    Article  CAS  Google Scholar 

  21. Taheri S, Ward H, Ghatei M, Bloom S . Role of orexins in sleep and arousal mechanisms Lancet 2000 355: 847.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Funding for this work was provided by Autogen Ltd., Australia and Merck-Lipha, Germany.

Author information

Authors and Affiliations

  1. Metabolic Research Unit, School of Health Sciences, Deakin University, Victoria, Australia

    K Walder, JS McMillan, S Lee, A Civitarese & GR Collier

  2. International Diabetes Institute, Caulfield, Victoria, Australia

    P Zimmet

Authors
  1. K Walder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JS McMillan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Civitarese
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P Zimmet
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. GR Collier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K Walder.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walder, K., McMillan, J., Lee, S. et al. Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats). Int J Obes 25, 1281–1285 (2001). https://doi.org/10.1038/sj.ijo.0801662

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijo.0801662

Keywords

This article is cited by

Search

Advanced search

Quick links