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Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents

International Journal of Obesity volume 24, pages 1459–1464 (2000)Cite this article

Abstract

OBJECTIVE: To investigate the contribution of serum lipids, parameters of glucose metabolism, body composition and cardiovascular fitness to the variance of several haemostatic risk factors for coronary heart disease (CHD) in obese children and adolescents.

SUBJECTS AND MEASUREMENTS: Forty-two healthy, obese children and adolescents (20 male, 22 female, age 12.6±3.2 y; body mass index (BMI), 30.4±5.3 kg/m2), were screened for haemostatic and metabolic risk factors for CHD. Thirty-five of the participants (18 male, age 13.5±2.9 y; BMI, 29.9±4.5 kg/m2; 17 female, age 12.8±2.1 y, BMI, 31.1±5.3 kg/m2) were assessed for cardiovascular fitness by means of incremental cycle ergometer exercise.

RESULTS: After adjustment for age, fat mass correlated significantly with plasminogen activator inhibitor-1 antigen (PAI-1-Ag) in boys and girls and factor VIIc only in girls. Children with lower power output (≤ 2.77 W/kg) showed significantly higher values for factor VIIc, fibrinogen and tissue-type plasminogen activator antigen (tPA-Ag). Neither body composition nor cardiovascular fitness contributed independently to the variance of the determined haemostatic risk factors, except PAI-1-Ag, which has been shown to be determined by fat mass. In multiple linear regression analysis, triglycerides and PAI-1-Ag explained significant independent proportions of the variance of tPA-Ag. Factor VIIc was explained by C-peptide, insulin and fibrinogen. Von Willebrand factor antigen (vWF-Ag) was significantly related to glucose and insulin.

CONCLUSION: The results suggest that in obese children and adolescents the haemostatic risk factors factor VIIc, vWF-Ag and tPA-Ag are mainly determinated by plasma insulin and triglyceride concentrations, but are primarily independent of body composition and cardiovascular fitness.

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Acknowledgements

The study was supported by a grant from the Gesellschaft zur Foerderung der Gesundheit des Kindes (EVITA).

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Authors and Affiliations

  1. Department of Pediatrics, Ludwig Boltzmann Research Institute for Paediatric Haemostasis and Thrombosis, Graz, Austria

    S Gallistl & W Muntean

  2. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Graz, Austria

    M Borkenstein, M Troebinger & G Weinhandl

  3. Institute for Sport Sciences, University of Graz, Austria

    KM Sudi

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  1. S Gallistl
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Correspondence to S Gallistl.

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Gallistl, S., Sudi, K., Borkenstein, M. et al. Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents. Int J Obes 24, 1459–1464 (2000). https://doi.org/10.1038/sj.ijo.0801427

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