Abstract
The relationship between heterozygosity at nine polymorphic enzyme loci and disease resistance was examined in 373 individually identified rainbow trout (Oncorhynchus mykiss) from 12 full-sib families and a pooled gamete cross. These fish were challenged with bacterial gill disease, a potentially lethal epizootic in freshwater fishes. The 213 surviving fish had significantly greater numbers of heterozygous loci per fish and were significantly larger than the 160 individuals that died. Survivors, on average, had higher heterozygosity at six out of nine loci than non-survivors. The differences were significant at three of these loci. These findings suggest that more heterozygous rainbow trout have superior disease resistance than less heterozygous fish.
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Allendorf, F W, and Leary, R F. 1986. Heterozygosity and fitness in animals. In Soule, M. E. (ed.) Conservation Biology, Sinauer, Sunderland, pp. 57–76.
Allendorf, F W, Mitchell, N J, Ryman, N, and Stahl, G. 1977. Isozyme loci in brown trout (Salmo trutta L.): detection and interpretation from population data. Hereditas, 86, 179–190.
Allendorf, F W, and Thorgaard, G H. 1984. Tetraploidy and the evolution of salmonid fishes. In Turner, B. J. (ed.) Evolutionary Genetics of Fishes, Plenum, New York, pp. 1–53.
Allison, A C. 1955. Aspects of polymorphism in man. Cold Spring Harbor Symp. Quant Biol, 20, 239–255.
Black, F L, and Salzano, F M. 1981. Evidence for heterosis in the HLA system. Am J Hum Genet, 33, 894–899.
Chakraborty, R. 1981. The distribution of the number of heterozygous loci in an individual in natural populations. Genetics, 98, 461–466.
Danzmann, R G, Ferguson, M M, and Allendorf, F W. 1986. Does enzyme heterozygosity influence developmental rate in rainbow trout Heredity, 56, 417–425.
Danzmann, R G, Ferguson, M M, and Allendorf, F W. 1987. Heterozygosity and oxygen consumption rate as predictors of growth and developmental rate in rainbow trout. Physiol Zool, 60, 211–220.
Danzmann, R G, Ferguson, M M, and Allendorf, F W. 1988. Heterozygosity and components of fitness in a strain of rainbow trout. Biol J Linn Soc, 33, 285–304.
Degos, L, Colomboni, J, Chaventre, A, Bengston, B, and Jacguard, A. 1974. Selective pressure on HLA polymorphism. Nature, 249, 62–63.
Ferguson, M M. 1990. Enzyme heterozygosity and growth of rainbow trout reared at two rations. Biol J Linn Soc (in press).
Ferguson, M M, Danzmann, R G, and Allendorf, F W. 1985. Developmental divergence among hatchery strains of rainbow trout (Salmo gairdneri). I. Pure strains. Can J Genet Cytol, 27, 289–297.
Frelinger, J A. 1972. The Maintenance of Transferrin Polymorphism in Pigeons. Proc Natl Acad Sei Usa, 69, 326329.
From, J. 1980. Chloramine-T for the control of bacterial gill disease. Prog Fish-Cult, 42, 85–86.
Leary, R F, Allendorf, F W, and Knudsen, K L. 1987. Differences in Inbreeding Coefficients Do Not Explain The Association Between Heterozygosity At Allozyme Loci and Developmental Stability in Rainbow Trout. Evolution, 41, 1413–1415.
Mitton, J B, and Grant, M C. 1984. Associations among protein heterozygosity, growth rate and developmental homoestasis. Ann Rev Ecol Syst, 15, 479–499.
O'Brien, S J, Roelke, M E, Marker, L, Newman, A, Winkler, C A, Meltzer, D, Colly, L, Evermann, J F, Bush, M, and Wildt, D E. 1985. Genetic Basis For Species Vulnerability in The Cheetah. Science, 227, 14281434.
Samollow, P B, and Soule, M E. 1983. A case of stress related heterozygote superiority in nature. Evolution, 37, 646–649.
Schachte, J H. 1983. Bacterial gill disease. In Meyer, F. P., Warren, J. W. and Carey, T. G. (eds) A Guide to Integrated Fish Health Management in the Great Lakes Basin, Great Lakes Fishery Commission, Ann Arbor, Michigan, Spec. Pub. 83–2, pp. 181–184.
Wills, C. 1981. Genetic Variability. Clarendon Press, Oxford.
Zouros, E. 1987. On the Relation Between Heterozygosity and Heterosis: An Evaluation of the Evidence from Marine Mollusks. In Rattazzi, M. C, Scandalios, J. G.And Whitt, G. S. (Eds) Isozymes, VOL. 15, Liss, New York, pp. 255–270.
Zouros, E, and Foltz, D W. 1987. The use of allelic isozyme variation for the study of heterosis. In Rattazzi, M. C, Scandalios, J. G. and Whitt, G. S. (eds) Isozymes, vol. 13, Liss, New York, pp. 1–59.
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Ferguson, M., Drahushchak, L. Disease resistance and enzyme heterozygosity in rainbow trout. Heredity 64, 413–417 (1990). https://doi.org/10.1038/hdy.1990.52
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DOI: https://doi.org/10.1038/hdy.1990.52
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