Abstract
A general method to estimate allele frequencies when there are more than two alleles segregating in an autosomal and only the heterozygotes can be identified is presented. The particular three allele case is detailed and the method is applied to chromosomal inversion data of Drosophila mediopunctata. The estimates from egg sample data are compared with those from adult male sample data. No significant differences were found between the two methods. However, the combined use of both data unveiled significant variations in the frequencies of inversions at different collecting times, that otherwise would not have been detected. Furthermore, the method is applied to data on inversion frequencies of D. nebulosa, D. willistoni and D. flavopilosa.
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Arnold, J. 1981. Statistics of natural populations. I. Estimating an allele probability in cryptic fathers with a fixed number of offspring. Biometrics, 31, 145–160.
Barth, R. 1957. A fauna do Parque Nacional do Itatiaia. Bol Pq Nac Itatiaia, (6).
Brade, A. 1956. A flora do Parque Nacional do Itatiaia. Bol Pq Nac Itatiaia, (5).
Brncic, D. 1966. Ecological and cytogenetic studies of Drosophila flavopilosa, a neotropical species living in Cestrum flowers. Evolution, 20, 16–29.
Clyde, M. 1982. Inversion polymorphism in Southeast Asian populations of Drosophila nasuta subgroup. Genetica, 58, 161–175.
Cotterman, C. 1953. Regular Two-Allele and Three-Allele Phenotype Systems, PART I. Amer J Hum Genet, 5, 193235.
Da Cunha, A, Brncic, D, and Salzano, F. 1953. A comparative study of polymorphism in certain South American species of Drosophila. Heredity, 7, 193–202.
Da Cunha, A, Burla, H, and Dobzhansky, T H. 1950. Adaptive chromosomal polymorphism inDrosophila willistoni. Evolution, 4, 212–235.
Dobzhansky, T H. 1970. Genetics of the Evolutionary Process. Columbia University Press, New York.
Dobzhansky, T H, and Levene, H. 1948. Genetics of natural populations. XVII. Proof of operation of natural selection in wild populations of Drosophila pseudoobscura. Genetics, 33, 537–547.
Kumar, A, and Gupta, J. 1988. Genetics of natural populations of Drosophila nasuta. J Hered, 79, 83–88.
Mather, W B, and Thongmeearkom, P. Chromosome map of D. albomicans. Dros. Inf. Serv., 55, 101–102.
Peixoto, A, and Klaczko, L B. 1987. Polimorfismos de inversões cromossoocirc;micas em Drosophila mediopunctata. II: Desequilibrio de ligação. Ciência e Cultura, 39, (supl.), 767.
Regner, L, and Valente, V. 1988. Comportamento sexual e polimorfismo cromossômico em Drosophila nebulosa. Ciência e Cultura, 40, (supl.), 769.
Sperlich, D, and Pfriem, P. 1986. Chromosomal polymorphism in natural and experimental populations. In Ashburner, M., Carson, H. L. and Thompson, J. N. (eds) The Genetics and Biology of Drosophila, Vol. 3e, Academic Press.
Valente, V, and Araujo, A. 1986. Chromosomal polymorphism, climatic factors and variation in population size of D. willistoni in Southern Brazil. Heredity, 57, 149–159.
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Klaczko, L., Otto, P. & Peixoto, A. Allele frequency estimates when only heterozygotes can be recognized: method of estimation and application in the case of chromosomal inversion polymorphisms in Drosophila. Heredity 64, 263–270 (1990). https://doi.org/10.1038/hdy.1990.32
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DOI: https://doi.org/10.1038/hdy.1990.32
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