Volume 30 Issue 7-8, August 2023

Cover Credit: Gene Therapy to reduce astrogliosis in ALS motor cortex. Astrogliosis and microgliosis contribute to upper motor neuron degeneration in ALS, especially within the context of TDP-43 pathology. The image shows that cortical component of ALS can be modulated by intrathecal injection of AAV9 expressing HGF gene under the control of a novel and engineered promoter. This gene therapy approach significantly reduces astrogliosis and microgliosis that occurs in the ALS motor cortex with TDP-43 pathology.