Volume 30 Issue 12, December 2023

Cover Credit: The equine model of post-traumatic osteoarthritis is a powerful tool to translate therapeutic effects of intra-articular therapies, specifically gene therapies, in people. The equine model used here and described within this issue, demonstrates optimal doses of scAAVIL-1ra that have maximal anti-inflammatory effects but also identifies doses of vector that are either too high resulting in nonoptimal synovial capsule changes or doses that are too low that do not control inflammation within the joint. This highly relevant pre-clinical model of osteoarthritis will inform intra-articular dosing regimens in people due to the similarities between horses and humans regarding joint anatomy, physiology and osteoarthritis disease progression.