Volume 29 Issue 7-8, August 2022

Cover Credit:AAV-mediated gene augmentation therapy holds great promise to rescue vision in retinal degenerative diseases. The image shows the retina of Rs1^−/y transgenic rat model of X-linked retinoschisis rescued by retinoschisin (RS1) expressed from the AAV-RS1 vector. The retinal structures preserved are photoreceptor inner segments highlighted by RS1 (red band at the top) and synaptic contacts (yellow mesh) that are maintained between photoreceptor pre-synaptic output (RS1, red) and post-synaptic inputs to depolarizing bipolar cells (PCKa, green).