TABLE OF CONTENTS

Volume 15, Issue 11 (June 2008)

Special Issue: AAV Vectors for Clinical Gene Therapy

Guest Editor: Robert M Kotin, National Institutes of Health, Bethesda, MD, USA

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Editorial

Introduction to AAV Vector special issue FREE

M Nirenberg

Gene Ther 15: 807; doi:10.1038/gt.2008.62

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Review Articles

Immunity to adeno-associated virus vectors in animals and humans: a continued challenge FREE

A K Zaiss and D A Muruve

Gene Ther 15: 808-816; advance online publication, April 3, 2008; doi:10.1038/gt.2008.54

Adeno-associated virus integration: virus versus vector FREE

R H Smith

Gene Ther 15: 817-822; advance online publication, April 10, 2008; doi:10.1038/gt.2008.55

Toward exascale production of recombinant adeno-associated virus for gene transfer applications FREE

S Cecchini, A Negrete and R M Kotin

Gene Ther 15: 823-830; advance online publication, April 10, 2008; doi:10.1038/gt.2008.61

Potential of AAV vectors in the treatment of metabolic disease FREE

I E Alexander, S C Cunningham, G J Logan and J Christodoulou

Gene Ther 15: 831-839; advance online publication, April 10, 2008; doi:10.1038/gt.2008.64

Manufacturing and characterizing AAV-based vectors for use in clinical studies FREE

J F Wright

Gene Ther 15: 840-848; advance online publication, April 17, 2008; doi:10.1038/gt.2008.65

AAV-mediated gene therapy for retinal disorders: from mouse to man FREE

P K Buch, J W Bainbridge and R R Ali

Gene Ther 15: 849-857; advance online publication, April 17, 2008; doi:10.1038/gt.2008.66

Clinical gene therapy using recombinant adeno-associated virus vectors FREE

C Mueller and T R Flotte

Gene Ther 15: 858-863; advance online publication, April 17, 2008; doi:10.1038/gt.2008.68

AAV vectors for RNA-based modulation of gene expression FREE

O Danos

Gene Ther 15: 864-869; advance online publication, April 17, 2008; doi:10.1038/gt.2008.69

AAV-mediated gene transfer for the treatment of hemophilia B: problems and prospects FREE

N C Hasbrouck and K A High

Gene Ther 15: 870-875; advance online publication, April 24, 2008; doi:10.1038/gt.2008.71