Figure 9 - Effect of recombinant hemoglobin that inactivates nitric oxide on esophageal peristalsis in a human subject.
From the following article
Pathophysiology of achalasia and diffuse esophageal spasm
Ikuo Hirano
GI Motility online (2006)
doi:10.1038/gimo22
Control manometry (a) reveals a sequential peristaltic wave and normal LES relaxation in response to a swallow. Following an infusion of hemoglobin (b), deglutition produces simultaneous esophageal contraction and absent LES relaxation, mimicking the manometric profile of achalasia. (Source: Murray et al.39 with permission from American Gastroenterological Association.)
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