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Cloning and characterization of TNKL, a member of tankyrase gene family

Genes & Immunity volume 2, pages 52–55 (2001)Cite this article

Abstract

By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

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Authors and Affiliations

  1. Laboratory of Molecular Immunology, A.N. Belozersky Institute of Physico-Chemical Biology and Center for Molecular Medicine, Moscow State University, Moscow, 119899, Russia

    AN Kuimov, VN Petrov, KK Vdovichenko, MA Lagarkova & SA Nedospasov

  2. Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia

    DV Kuprash & SA Nedospasov

  3. Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, NY 10021, New York, USA

    MJ Scanlan

  4. Ludwig Institute for Cancer Research, Office of Information Technology, Epalinges, CH-1066, Switzerland

    CV Jongeneel

Authors
  1. AN Kuimov
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  2. DV Kuprash
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  3. VN Petrov
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  4. KK Vdovichenko
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  5. MJ Scanlan
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  6. CV Jongeneel
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  7. MA Lagarkova
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  8. SA Nedospasov
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Corresponding author

Correspondence to SA Nedospasov.

Additional information

This project has been funded by the Ludwig Institute for Cancer Research, and by grants 00-04-48300 (ANK) and 98-04-49031 (MAL) from the Russian Foundation for Basic Research.

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Kuimov, A., Kuprash, D., Petrov, V. et al. Cloning and characterization of TNKL, a member of tankyrase gene family . Genes Immun 2, 52–55 (2001). https://doi.org/10.1038/sj.gene.6363722

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  • DOI: https://doi.org/10.1038/sj.gene.6363722

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