In mammals, unfertilized eggs and corpora lutea originate from Graafian follicles in the ovary. Two recent reports support the view that to produce Graafian follicles, oocytes and surrounding granulosa cells must communicate with each other. However, there is evidence to suggest that oocyte development can take place in the absence of granulosa cells.
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Wassarman, P. Channels of communication in the ovary. Nat Med 8 (Suppl 10), S7–S9 (2002). https://doi.org/10.1038/nm-fertilityS7
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DOI: https://doi.org/10.1038/nm-fertilityS7
