Abstract
Immunohistochemical staining of conjunctival biopsies from four normal subjects and five patients with atopic keratoconjunctivitis (AKC) was performed, using a monoclonal antibody to human mast cell tryptase. A massive hyperplasia of mast cells in the patients with AKC was demonstrated. The mean mast cell density in the normal patients was 55.6/mm2 and in the patients with AKC, 172/mm2. The appearance of large numbers of mast cells in the conjunctival epithelium of AKC patients was also demonstrated. The possible pathophysiological significance of these findings is discussed.
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The Southampton & South West Hants Ethical Committee gave its approval of this study.
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Morgan, S., Williams, J., Walls, A. et al. Mast cell hyperplasia in atopic keratoconjunctivitis . Eye 5, 729–735 (1991). https://doi.org/10.1038/eye.1991.134
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DOI: https://doi.org/10.1038/eye.1991.134
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