Abstract
The histopathology of tumours originating at the corneoscleral limbus is reviewed with special reference to some 636 specimens examined over a 40 year period at the Institute of Ophthalmology, London. Over half the lesions involved melanocytes (351 cases) derived from the limbal conjunctiva and of these two-thirds were benign naevi. Conversely, benign squamous cell tumours were rare, only five unequivocal papillomas having been seen compared with 137 premalignant lesions and 73 carcinomas. Solid dermoids accounted for approximately 10 per cent of all tumours involving the limbus.
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Mattos J, Contreras F, O'Donnell FE Jr: Ring dermoid syndrome: a new syndrome of autosomal dominantly inherited, bilateral, annular limbal dermoids with corneal and conjunctival extension. Arch Ophthalmol 1980, 98: 1059–61.
Sugar HS : The oculoauriculovertebral syndrome of Goldenhar. Am J Ophthalmol 1966, 62: 678–82.
Erie JC, Campbell RJ, Liesegang TJ : Conjunctival and corneal intraepithelial and invasive neo-plasia. Ophthalmol 1986, 93: 176–83.
Folberg R, McLean IW, Zimmerman LE : Primary acquired melanosis of the conjunctiva. Hum Pathol 1985, 16: 129–35.
Zimmerman LE : The cancerous, precancerous and Pseudocancerous lesions of the cornea and con junctiva. In Rycroft PV ed. Corneo-Plastic Surgery. Oxford: Pergamon, 1969: 547–555.
Reese AB : Precancerous and cancerous melanosis. Am J Ophthalmol 1966, 61: 1272–7.
Folberg R, McLean IW, Zimmerman LE : Malignant melanoma of the conjunctiva. Hum Pathol 1985, 16: 136–43.
Allen AC and Spitz S : Malignant melanoma; a clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer 1953, 6: 1–45.
Silvers DN, Jakobiec FA, Freeman TF, Lefkowitch JH, Ellie RC : Melanoma of the conjunctiva: a clinicopathologic study. In Jakobiec FA ed. Ocular and Adnexal Tumors. Birmingham, Ala: Aesculapius 1978: 583–99.
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Garner, A. The pathology of tumours at the limbus. Eye 3, 210–217 (1989). https://doi.org/10.1038/eye.1989.30
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DOI: https://doi.org/10.1038/eye.1989.30