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| Original paper |
| A second Middle Eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9 |
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| Suzanne M Leal1,2,a, Fazil Apaydin3, Carol Barnwell4, Metin Iber3, Tolga Kandogan3, Markus Pfister2, Uwe Braendle2, Orhan Cura3, Marvin Schwalb4, Hans-Peter Zenner2 and Emilia Vitale4 |
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1Laboratory of Statistical Genetics, Rockefeller University, New York, USA
2Department of Otolaryngology, University of Tübingen, Germany
3Department of Otolaryngology, Ege University Medical School, Izmir, Turkey
4Department of Microbiology and Molecular Genetics, New Jersey Medical School, Newark, USA
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aCorrespondence: Dr Suzanne M Leal, Laboratory of Statistical Genetics, 1230 York, Avenue, Box 192, New York, NY 10021-6399. Tel: 1 (212) 327 7992; Fax: 1 (212) 327 7996; E-mail: lealsm@rockvax.rockefeller.edu |
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| Abstract |
| A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM). |
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| Keywords |
| Autosomal recessive non-syndromic hearing loss; sensorineural hearing loss; DFNB9 |
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| Received 25 August 1997; revised 12 January 1998; accepted 13 January 1998 |
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| July 1998, Volume 6, Number 4, Pages 341-344 |
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