Original Article

European Journal of Clinical Nutrition (2008) 62, 1187–1193; doi:10.1038/sj.ejcn.1602842; published online 11 July 2007

Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan

Contributors: SY: writing of the paper and data analysis; KM: writing of the paper, data analysis and data collection in Toyama center; KI: design, measurement and quality control of urinary selenium; KY: design and quality control of nutritional survey; HN: study design, principal investigator of Toyama center and writing of the paper; TS: design and quality control of urinary selenium; AO: study design and principal investigator of Aito Town center; KS: study design and principal investigator of Wakayama center; SS: study design and principal investigator of Sapporo center; HU: study design, principal investigator of INTERMAP Japan and writing of the paper; PE: study design; principal investigator of INTERMAP international study and writing of the paper, JS: study design, principal investigator of INTERMAP international study and writing of the paper.

S Yoneyama1, K Miura1, K Itai2, K Yoshita3, H Nakagawa1, T Shimmura4, A Okayama5, K Sakata2, S Saitoh6, H Ueshima7, P Elliott8 and J Stamler9 for the INTERMAP Research Group

  1. 1Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
  2. 2Department of Hygiene and Preventive Medicine, Iwate Medical University, Iwate, Japan
  3. 3Division of Health and Nutrition Monitoring, National Institute of Health and Nutrition, Tokyo, Japan
  4. 4Department of Environmental Health, Toyama Institute of Health, Toyama, Japan
  5. 5Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
  6. 6Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
  7. 7Department of Health Science, Shiga University of Medical Science, Shiga, Japan
  8. 8Department of Epidemiology and Public Health, Faculty of Medicine, St Mary's Campus, Imperial College, London, UK
  9. 9Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

Correspondence: Dr K Miura, Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. E-mail: miura@kanazawa-med.ac.jp

Received 27 April 2006; Revised 8 March 2007; Accepted 27 April 2007; Published online 11 July 2007.

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Abstract

Objective:

 

This study is to examine the relationship between dietary selenium intake and 24-h urinary selenium excretion in Japanese population samples participating in the INTERMAP Study.

Methods:

 

Using highly standardized methods, we assessed individual dietary selenium intake from four 24-h dietary recalls and measured urinary selenium excretion in two timed 24-h urine collections in 1145 Japanese participants (574 men and 571 women) ages 40–59 years in four areas of Japan.

Results:

 

The medians of dietary selenium intake were 177.5 mug/day in men and 139.8 mug/day in women; the medians of 24-h urinary selenium excretion were 127.9 mug/day in men and 109.4 mug/day in women, that is, urinary excretion was estimated to be 73% of dietary intake in men and 77% in women. Dietary selenium intake was significantly correlated with 24-h urinary selenium excretion (r=0.24 in men, r=0.18 in women; P<0.001). With dietary selenium intake and urinary selenium excretion expressed per kg of body weight, values were similar for men and women (dietary intake, 2.7 mug/kg body weight in men and 2.5 mug/kg body weight in women; urinary excretion, 2.0 mug/kg body weight in men and 2.0 mug/kg body weight in women).

Conclusion:

 

Dietary intake and 24-h urinary excretion of selenium are related in the Japanese adult population.

Keywords:

dietary selenium intake, urinary selenium excretion, epidemiology, Japanese

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