Abstract
Objective:
To compare the effects of two energy-restricted healthy diets, one with a low GI and one with a high GI, on heart disease risk factors and weight loss in subjects at risk of heart disease.
Design:
A 12-week randomized parallel study of low and high GI, healthy eating diets was carried out.
Setting:
The study was carried out at the Hammersmith Hospital.
Subjects:
Eighteen subjects were recruited by advertisement and randomized to one of the two diets. Fourteen completed the study but one was excluded from the final analysis.
Methods:
At randomization, subjects were advised to follow the intervention diet for 12 weeks. Before randomization and on completion of the study, anthropometrics, fasting cholesterol and glucose blood tests and 24-h glucose measurements were taken using a continuous glucose monitoring system (CGMS). Statistical analysis was carried out using non-parametric tests. Median (IQR) are presented.
Results:
A significantly different dietary GI was achieved in the low GI (median: 51.3 (IQR: 51.0–52.0) compared to the high GI (59.3 (59.2–64.0) (P=0.032) group. By week 12, both groups reduced their energy intake by: low GI group: −167 (−312–−123) kcal/day (P=0018) vs high GI group: –596 (−625–−516) (P=0.018) kcal/day, the difference between the groups being significant (P=0.010). However, only the low GI group lost weight (−4.0 (−4.4–−2.4) kg (P=0.018) whereas the high GI group did not significantly change in weight (−1.5 (−3.6–0.8) kg (P=0.463). By week 12, the low GI group also had a significantly lower 24-h area under the curve (AUC) (7556 (7315–8434) vs 8841 (8424–8846) mmol-h/l (P=0.045) and overnight AUC (2429 (2423–2714) vs 3000 (2805–3072) mmol-h/l (P=0.006) glucose as measured by CGMS. There were no differences in the other heart disease risk factors assessed.
Conclusions:
This pilot study provides some evidence that consuming a low GI diet in addition to weight loss and healthy eating may reduce cardiovascular risk. Other potential benefits of GI might have been masked by weight loss in the low GI group. Larger-scale studies need to follow.
Sponsorship:
The study was funded by the British Heart Foundation.
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References
Alfenas RCG, Mattes RD (2005). Influence of glycemic index/load on glycemic response, appetite, and food intake in healthy humans. Diabet Care 28, 2123–2129.
Brand-Miller JC, Holt SH, Pawlak DB, McMillan J (2002). Glycemic index and obesity. Am J Clin Nutr 76, 281S–285S.
Brownlee M (1994). Glycation and diabetic complications. Diabetes 43, 836–841.
Carlsson M, Wessman Y, Almgren P, Groop L (2000). High levels of nonesterified fatty acids are associated with increased familial risk of cardiovascular disease. Arterioscler Thromb Vasc Biol 20, 1588–1594.
Coutinho M, Gerstein HC, Wang Y, Yusuf S (1999). The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95 783 individuals followed for 12.4 years. Diabet Care 22, 233–240.
Foster-Powell K, Holt SH, Brand-Miller JC (2002). International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76, 5–56.
Frost GS, Brynes AE, Adamson J, Dornhorst A (2005). The beneficial effect of a low glycaemic diet on 24-hour blood glucose profiles in healthy people as assessed by continuous glucose monitoring. Br J Nutr 93, 179–182.
Giugliano D, Ceriello A, Paolisso G (1996). Oxidative stress and diabetic complications. Diabet Care 19, 257–267.
Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM et al. (1981). Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34, 362–366.
Kelly S, Frost G, Whittaker V, Summerbell C (2004). Low glycaemic index diets for coronary heart disease. Cochrane Database Syst Rev 4, CD004467.
Ludwig DS (2002). The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 287, 2414–2423.
Murray CJ, Lopez AD (1997). Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349, 1269–1276.
Raatz SK, Torkelson CJ, Redmon JB, Reck KP, Kwong CA, Swanson JE et al. (2005). Reduced glycemic index and glycemic load diets do not increase the effects of energy restriction on weight loss and insulin sensitivity in obese men and women. J Nutr 135, 2387–2391.
Reaven GM (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595–1607.
Rizkalla SW, Taghrid L, Laromiguiere M, Huet D, Boillot J, Rigoir A et al. (2004). Improved plasma glucose control, whole-body glucose utilization, and lipid profile on a low-glycemic index diet in type 2 diabetic men: a randomized controlled trial. Diabet Care 27, 1866–1872.
Sachedina N, Pickup JC (2003). Performance assessment of the Medtronic-MiniMed Continuous Glucose Monitoring System and its use for measurement of glycaemic control in Type 1 diabetic subjects. Diabet Med 20, 1012–1015.
The DECODE Study Group (2001). Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 161, 397–405.
Thorburn A, Muir J, Proietto J (1993). Carbohydrate fermentation decreases hepatic glucose output in healthy subjects. Metabolism 42, 780–785.
Vlassara H, Bucala R, Striker L (1994). Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 70, 138–151.
Wolever TM (2003). Carbohydrate and the regulation of blood glucose and metabolism. Nutr Rev 61 (5 Part 2), S40–S48.
Wolever TMS, Mehling C (2003). Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol, and free fatty acid concentrations in subjects with impaired glucose tolerance. Am J Clin Nutr 77, 612–621.
Wood D, Wray R, Poulter N, Williams B, Kirby M, Patel V et al. (2005). JBS 2: joint British societies' guidelines on prevention of cardiovascular disease in clinical practice. Heart 91 (Suppl V), v1–v52.
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Guarantor: GS Frost.
Contributors: EP participated in study design, enrolled volunteers, did the study, analysed the data and wrote the manuscript. BMCMcG medically screened volunteers and reviewed the manuscript. AEB participated in study design, analysis of data and manuscript preparation and overviewed the project. AD participated in study design and reviewed the manuscript. ARL conceived the study and participated in study design. GSF conceived the study, participated in study design, analysis of data and manuscript preparation and overviewed the project.
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Philippou, E., McGowan, B., Brynes, A. et al. The effect of a 12-week low glycaemic index diet on heart disease risk factors and 24 h glycaemic response in healthy middle-aged volunteers at risk of heart disease: a pilot study. Eur J Clin Nutr 62, 145–149 (2008). https://doi.org/10.1038/sj.ejcn.1602688
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DOI: https://doi.org/10.1038/sj.ejcn.1602688
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