Abstract
Objective: Whey-based formulas have faster gastric emptying than casein-based formulas. Isoenergetic, isovolumic, whey-based formulas of different osmolarity and fat content empty in a similar manner. Will the gastric emptying of high and low energy density whey-based formulas be similar?
Design: We studied the gastric emptying rate of equal volumes of two whey-based formulas of different energy density (4.18 kJ/ml and 6.27 kJ/ml) and osmolality (270 and 450 mOsm/kg, respectively) in 10 children (4.5–12 y) with volume intolerance and resultant inability to gain weight.
Results: The two formulas had comparable gastric emptying rates at 30, 60, 90 and 120 min. Over a one month clinical trial, substitution of the lower energy density whey-based formula (no weight gain over 2 months) with an equal volume of the high energy density formula produced a mean weight gain of 1.17±0.5 kg per patient without change in tolerance.
Conclusion: The higher density whey-based formula can safely substitute an equal volume of a lower energy density formula to produce weight gain without affecting tolerance.
Implication: This provides an important intervention for increasing energy intake in children with volume intolerance or fluid restriction.
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References
Billeaud C, Guillet J, Sandler B . 1990 Gastric emptying in infants with or without gastroesophageal reflux according to the type of milk Eur. J. Clin. Nutr. 44: 577–583
Fried MD, Khoshoo V, Secker DJ, Gilday DL, Ash JM, Pencharz PB . 1992 Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula J. Pediatr. 120: 569–572
Hunt JN, Stubbs DF . 1975 The volume and energy content of meals as determinants of gastric emptying J. Physiol. 245: 209–225
Hunt JN, Smith JL, Jiang CL . 1985 Effect of meal volume and energy density on the gastric emptying of carbohydrates Gastroenterology 89: 1326–1330
Khoshoo V, Zembo M, King A et al. 1996 Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment J. Pediatr. Gastroenterol. Nutr. 22: 48–55
Tolia V, Lin CH, Kuhns LR . 1992 Gastric emptying using three different formulas in infants with gastroesophageal reflux J. Pediatr. Gastroenterol. Nutr. 15: 297–301
Acknowledgements
This study was supported by a research grant from Nestle Clinical Nutrition Inc., Deerfield, IL, USA.
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Khoshoo, V., Brown, S. Gastric emptying of two whey-based formulas of different energy density and its clinical implication in children with volume intolerance. Eur J Clin Nutr 56, 656–658 (2002). https://doi.org/10.1038/sj.ejcn.1601373
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DOI: https://doi.org/10.1038/sj.ejcn.1601373