Abstract
Aim: The aim of our study was to evaluate the role of resuscitation as the risk factor for periventricular/ intraventricular hemorrhage in preterm newborns.
Methods: The one year prospective study involved 164 premature newborns, gestational age 23 to 32 weeks, transported from maternity hospital to the Institute for neonatology. According to the development of PVH/IVH three groups were formed. The first group (C- control) was formed of 39 newborns without PVH/IVH, second group (Mmild) involved 88 newborns with mild PVH/IVH and the third group 37 newborns who developed severe PVH/IVH (S- severe). The need for resuscitation was analyzed and compared between the groups, and the relative risk was calculated.
Results: The need for resuscitation using positive pressure ventilation (PPV) had 19 (48.7%) newborn from group C, 45 newborns (58.1%) from the group M and the 29 (79,4%)newborns from the group S. The difference was statistically significant, P< 0.05 (0.002). The difference was even more obvious (P< 0.001) comparing the use of sodium bicarbonate in resuscitation. As the part of resuscitation NaHCO3 received 5 (12.8%) newborns from the group C, 8 (9.1%) from the group M and 13 (35.2%) from the group. Calculated relative risk (RR 95% CI)) for developing severe form of PVH/IVH was 2.12 (0.97 - 4.62) when PPV is performed and 2.87 (1.69 - 4.88) after the use of NaHCO3.
Conclusion: Beside immaturity, the need for resuscitation may represent significant risk factor for the development of PVH/IVH in premature newborns, especially if the NaHCO3. was used.
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Nikolic, T., Jankovic, B., Otasevic, B. et al. 601 Resuscitation and Periventricular/ Intraventricular Hemorrhage. Pediatr Res 68 (Suppl 1), 308 (2010). https://doi.org/10.1203/00006450-201011001-00601
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DOI: https://doi.org/10.1203/00006450-201011001-00601