Abstract
ABSTRACT: The leukocyte glycoprotein l-selectin mediates an early step in the recruitment of leukocytes to sites of inflammation. l-Selectin surface expression is rapidly down-regulated by inflammatory signals in vitro. In a prospective study, we found l-selectin expression on umbilical cord blood granulocytes and monocytes to be significantly decreased in newborn infants with acute bacterial infection compared with controls (p < 0.01). A significantly reduced l-selectin expression of both granulocytes and monocytes was also found to be associated with an increased neutrophil immature/total ratio (p < 0.01) but not with other laboratory markers of neonatal sepsis. There was no apparent impact of prematurity, low birth weight, gestational hypertension, or gestational diabetes on l-selectin expression. Although the mode of delivery did not affect granulocyte l-selectin expression, umbilical cord blood monocytes showed an increased l-selectin expression after emergency cesarean delivery compared with samples obtained after elective cesarean or vaginal delivery (p < 0.01). We conclude that acute systemic inflammation results in down-regulation of granulocyte and monocyte l-selectin expression in vivo similar to that observed in vitro.
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Bührer, C., Graulich, J., Stibenz, D. et al. L-Selectin Is Down-regulated in Umbilical Cord Blood Granulocytes and Monocytes of Newborn Infants with Acute Bacterial Infection. Pediatr Res 36, 799–804 (1994). https://doi.org/10.1203/00006450-199412000-00020
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DOI: https://doi.org/10.1203/00006450-199412000-00020
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