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Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients

Oncogene volume 22, pages 7222–7224 (2003)Cite this article

Abstract

The lipid mediator platelet-activating factor (PAF) plays a role in cancer. We investigated its presence in human colon carcinoma by assessing the levels of tissue phospholipase A2 (PLA2, the key enzyme in the generation of the lyso-PAF precursor), lyso-PAF, PAF and acetylhydrolase activity (AHA, the key enzyme in PAF degradation) in colorectal cancer patients and by correlating them with Dukes' classification. The results highlighted that the tumour tissues of Dukes' A and B patients had significantly higher PLA2, lyso-PAF, PAF and AHA levels as compared with nontumour tissues. Dukes' C patients had higher PLA2, lyso-PAF and AHA levels but unchanged PAF. Dukes' D patients had higher AHA levels but unchanged PLA2, lyso-PAF and PAF. A pathophysiological role for PAF is suggested in human colon carcinoma.

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Acknowledgements

This work was supported by grants from ‘La Ligue Nationale Française Contre le Cancer’ (Comité de la Haute Vienne).

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Authors and Affiliations

  1. UMR CNRS 6101, Laboratoire d'Immunologie, Faculté de Médecine, 2 rue Dr Marcland, Limoges, 87025, France

    Yves Denizot & Laurence Guglielmi

  2. Service de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M Luther King, Limoges, 87042, France

    Alain Gainant, Stephane Bouvier, Pierre Cubertafond & Murielle Mathonnet

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  1. Yves Denizot
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Correspondence to Yves Denizot.

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Denizot, Y., Gainant, A., Guglielmi, L. et al. Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. Oncogene 22, 7222–7224 (2003). https://doi.org/10.1038/sj.onc.1207032

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