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MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese

Molecular Psychiatry volume 11, pages 748–751 (2006)Cite this article

Abstract

The MPZL1/PZR gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the MPZL1/PZR gene has been found to be significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating that MPZL1/PZR could be a potential schizophrenia marker. To test this hypothesis, we selected three single nucleotide polymorphisms (SNPs) for genotyping in 523 Han Chinese trios. We found that two individual SNPs were significant at the Bonferroni's corrected significance level P<0.017: rs3767444 (χ2=6.299, P=0.0121) and rs2051656 (χ2=9.856, P=0.0017). Haplotype transmission/disequilibrium tests revealed a significant association with the disease (global P-value=1.064 × 10−6), but no specific transmission distortions. Thus, we propose that the MPZL1/PZR gene may be important in the predisposition to schizophrenia among Han Chinese.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China, the National 973 and 863 Programs the Ministry of Education, PRC and the Shanghai Municipal Commission for Science and Technology. We thank NIH intramural support and the editorial assistance of the NCI, CCR Fellows Editorial Board.

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  1. G He and X Liu: These authors contributed equally to this work.

Authors and Affiliations

  1. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China

    G He, X Liu, W Qin, Q Chen, Y Yang & J Zhou

  2. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China

    G He, X Liu, W Qin, Q Chen, X Wang, Y Yang, J Zhou & L He

  3. NHGG, Bio-X, Shanghai Jiao Tong University, Shanghai, PR China

    X Wang & L He

  4. Shanghai Institute of Mental Health, Shanghai, PR China

    Y Xu, N Gu & G Feng

  5. Changchun Kaixuan Hospital, Changchun, PR China

    H Sang

  6. Wuhu No.4 People's Hospital, Wuhu, PR China

    P Wang

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  1. G He
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Correspondence to G He.

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He, G., Liu, X., Qin, W. et al. MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese. Mol Psychiatry 11, 748–751 (2006). https://doi.org/10.1038/sj.mp.4001841

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