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BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal aberration in a patient with TCRγδ+ T-cell acute lymphoblastic leukemia

Leukemia volume 22, pages 1266–1267 (2008)Cite this article

T-cell acute lymphoblastic leukemia (T-ALL) is a malignant disease of progenitor T cells that have undergone multiple genetic alterations. Translocations between T-cell receptor (TCR) genes and genes with oncogenic properties are a genetic hallmark of this disease. Most of these oncogenes encode transcription factors, the deregulated expression of which causes a block in the development of progenitor T cells.

Until recently, most of these TCR chromosomal rearrangements were attributed to erroneous recombinations involving the α/δ (TCRA/D) locus. However, new approaches uncovering cryptic chromosomal rearrangements revealed a higher incidence of TCRB locus-associated aberrations leading to the identification of new oncogenes involved in T-ALL leukemogenesis.1, 2

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Authors and Affiliations

  1. Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    N S D Larmonie, W A Dik, J J M van Dongen & A W Langerak

  2. Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    H B Beverloo

  3. Dutch Childhood Oncology Group, The Hague, The Netherlands

    E R van Wering

Authors
  1. N S D Larmonie
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  2. W A Dik
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  3. H B Beverloo
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  4. E R van Wering
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  5. J J M van Dongen
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  6. A W Langerak
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Correspondence to A W Langerak.

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The authors declare no competing financial interests.

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Larmonie, N., Dik, W., Beverloo, H. et al. BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal aberration in a patient with TCRγδ+ T-cell acute lymphoblastic leukemia. Leukemia 22, 1266–1267 (2008). https://doi.org/10.1038/sj.leu.2405026

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