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A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia

Leukemia volume 21, pages 2220–2221 (2007)Cite this article

ABL1 is a gene located in band 9q34 coding for a protein that has a tyrosine kinase activity. Its main fusion partner is a DNA sequence called BCR (breakpoint cluster region) involved in the t(9;22)(q34;q11) present in more than 95% of patients with chronic myeloid leukemia and in some 20% of the adults with pre-B acute lymphoblastic leukemia (ALL).1, 2

Few other ABL1 partners have been described. They are ETV6 rearranged in t(9;12)(q34;p13) rarely found in acute leukemia and myeloproliferative disorders,3, 4 NUP214 fused to ABL1 on amplified episomes in T-cell ALL,5 and EML1 rearranged in t(9;14)(q34;q32)-associated T-cell ALL.6 All three fusion proteins act as constitutively activated tyrosine kinases.4, 5, 6 Here we report the identification of a new putative ABL1 fusion partner, RCSD1, involved in a t(1;9)(q24;q34) translocation.

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Authors and Affiliations

  1. Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Brest, France

    E De Braekeleer, N Douet-Guilbert, F Morel & M De Braekeleer

  2. Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest, France

    N Douet-Guilbert, M-J Le Bris, F Morel & M De Braekeleer

  3. Service d'Hématologie Clinique, Institut de Cancérologie et d'Hématologie, CHU Morvan, Brest, France

    C Berthou

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  1. E De Braekeleer
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Correspondence to E De Braekeleer.

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De Braekeleer, E., Douet-Guilbert, N., Le Bris, MJ. et al. A new partner gene fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia. Leukemia 21, 2220–2221 (2007). https://doi.org/10.1038/sj.leu.2404773

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