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References
Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML et al. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 1995; 9: 1985–1989.
Borkhardt A, Cazzaniga G, Viehmann S, Valsecchi MG, Ludwig WD, Burci L et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin–Frankfurt–Munster Study Group. Blood 1997; 90: 571–577.
Romana SP, Le Coniat M, Berger R . t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosome Cancer 1994; 9: 186–191.
Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917–4921.
Mathew S, Shurtleff SA, Raimondi SC . Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia. Genes Chromosome Cancer 2001; 32: 188–193.
Reddy KS, Yang X, Mak L, Wang S, Johnston M . A child with ALL and ETV6/AML1 fusion on a chromosome 12 due to an insertion of AML1 and loss of ETV6 from the homolog involved in a t(12;15)(p13;q15). Genes Chromosome Cancer 2000; 29: 106–109.
Ford AM, Bennett CA, Price CM, Bruin MC, van Wering ER, Greaves M . Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci USA 1998; 95: 4584–4588.
Acknowledgements
This work was supported by the Leukaemia Research Fund. The authors are grateful for the kind donation of probes from Dr Peter Marynen, Leuven, Belgium (ETV6 cosmids); Dr Anne Hagemeijer, EU Concerted Action (ICRF c103 CO664) and Dr Roland Berger, Paris (H11086).
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Jalali, G., Martineau, M., Ford, A. et al. A unique variant of ETV6/AML1 fusion in a child with acute lymphoblastic leukemia. Leukemia 17, 993–995 (2003). https://doi.org/10.1038/sj.leu.2402873
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DOI: https://doi.org/10.1038/sj.leu.2402873