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Kinases: positive and negative regulators of apoptosis

Leukemia volume 14, pages 2019–2034 (2000)Cite this article

Abstract

Cells sense and respond to extracellular factors via receptors on the cell surface that trigger intracellular signaling pathways. The signals received by the receptors on hematopoietic cells often determine if the cell proliferates, survives or undergoes apoptosis. Apoptosis can be induced by almost any cytotoxic stimuli. These stimuli may be an absence of signals arising from cellular receptors, stimulation of specific ligand receptors on the cell surface, chemotherapeutic agents, and ionizing radiation or oxygen radicals, as well as a number of other factors. Cellular kinases and phosphatases participate in signaling cascades that influence this process. We review the ability of the calmodulin-dependent-kinases, I-κB kinases, PI3-kinases, Jak-kinases, PKC, PKA, and MAP kinase signaling pathways (Erk, Jnk, and p38), to influence the apoptotic process. In addition, we discuss the cross-talk that exists between signaling cascades that are pro-apoptotic and anti-apoptotic.

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Acknowledgements

This work was supported by a Scientist Development Grant from the American Heart Association (9930099N), an institutional research grant from the American Cancer Society (IRG-97–149), an Academic Research Initiation Grant from the North Carolina Biotechnology Center (9705-ARG-0009) awarded to RAF, a grant from the National Institutes of Health (R01 CA51025) and Academic Research Initiation Grants from the North Carolina Biotechnology Center (9805-ARG-0006 and 2000-ARG-0003) to JAM. We wish to acknowledge Dr Mikhail Blagosklonny, as well as both reviewers for providing feedback on this manuscript.

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  1. Department of Microbiology and Immunology and the Leo Jenkins Cancer Center, Brody School of Medicine at East Carolina, Greenville, NC, USA

    RA Franklin & JA McCubrey

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Franklin, R., McCubrey, J. Kinases: positive and negative regulators of apoptosis. Leukemia 14, 2019–2034 (2000). https://doi.org/10.1038/sj.leu.2401967

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