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The role of TEL fusion genes in pediatric leukemias

Leukemia volume 13, pages 6–13 (1999)Cite this article

Abstract

The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.

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Authors and Affiliations

  1. Department of Hematology/Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    JE Rubnitz & C-H Pui

  2. Department of Pathology and Laboratory Medicine, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    C-H Pui & JR Downing

  3. Department of Tumor Cell Biology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

    JR Downing

  4. Department of Pediatrics, University of Tennessee College of Medicine, Memphis, Tennessee, USA

    JE Rubnitz & C-H Pui

  5. Department of Pathology, University of Tennessee College of Medicine, Memphis, Tennessee, USA

    JR Downing

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  1. JE Rubnitz
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  2. C-H Pui
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  3. JR Downing
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Rubnitz, J., Pui, CH. & Downing, J. The role of TEL fusion genes in pediatric leukemias. Leukemia 13, 6–13 (1999). https://doi.org/10.1038/sj.leu.2401258

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  • DOI: https://doi.org/10.1038/sj.leu.2401258

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