Abstract
Four recent genome-wide screen studies in multiple sclerosis (MS) identified a number of candidate regions for susceptibility genes in addition to the HLA complex in 6p21. However, none of these regions provided formally significant evidence for genome-wide linkage. We have investigated such regions in 46 Swedish multiplex MS families, 28 singleton families, 190 sporadic MS patients and 148 normal controls by parametric and nonparametric linkage and association analysis. One microsatellite marker, in 12q23, provided evidence for association in addition to suggestive transmission distortion and slightly positive linkage. In addition, a marker in 7ptr–15 showed a significant transmission distortion as well as a highly significant score in affected pedigree member analysis, but not quite significant deviations in association analysis. One of three markers in 5p, a region implicated in all four previous studies, showed a weakly positive lod score, but no other evidence of importance. Markers in 2p23, 5q11–13, 6q25, 7q21–22, 11q21–23, 13q33–34, 16p13.2, 18p11.32–23, Xp21.3 provided little or no evidence of importance for MS. In summary, these data support the importance of genome-wide screens in the identification of new candidate loci in polygenic disorders.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Xu, C., Dai, Y., Fredrikson, S. et al. Association and linkage analysis of candidate chromosomal regions in multiple sclerosis: indication of disease genes in 12q23 and 7ptr–15. Eur J Hum Genet 7, 110–116 (1999). https://doi.org/10.1038/sj.ejhg.5200251
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejhg.5200251
Keywords
This article is cited by
-
Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes
Arthritis Research & Therapy (2009)
-
Follow-up investigation of 12 proposed linkage regions in multiple sclerosis
Genes & Immunity (2006)
-
A vulnerability locus to multiple sclerosis maps to 7p15 in a region syntenic to an EAE locus in the rat
Genes & Immunity (2004)
-
Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci
European Journal of Human Genetics (2001)
-
Linkage analysis suggests a region of importance for multiple sclerosis in 3p14–13
Genes & Immunity (2001)