Abstract
Objective: To investigate the effect of antioxidant supplementation on viral load and the antioxidant/reactive oxygen species system in people with HIV.
Design: Single centre, prospective, dose comparison study.
Setting: Outpatient clinic specializing in HIV care.
Subjects: Sixty-six participants were sequentially recruited by advertisement, and 48 subjects completed the study.
Interventions: A recommended dose antioxidant regimen (5450 IU vitamin A as β-carotene, 250 mg vitamin C, 100 IU vitamin E, 100 µg selenium, 50 mg coenzyme Q10) or a high-dose antioxidant regimen (21 800 IU vitamin A as β-carotene, 1000 mg vitamin C, 400 IU vitamin E, 200 µg selenium, 200 mg coenzyme Q10) for a 12 week period.
Results: Using repeated measures analysis of variance, the changes over treatment time were significant for selenium, glutathione, glutathione peroxidase and lipid peroxides (P<0.03). Changes in allantoin, uric acid and viral load were not significant (P>0.05). The main effects for group and the interaction effects were not significant for any of the parameters measured (P≥0.05).
Conclusion: Antioxidant supplementation significantly improved some measures of oxidative defence. There was no benefit in using a high-dose supplement in this study.
Sponsorship: Blackmores Ltd supplied the antioxidant supplements.
European Journal of Clinical Nutrition (2001) 55, 107–114
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Guarantor: Marijka Batterham.
Contributors: MB designed the study, was responsible for ethics approval and therapeutic goods administration approval, collected the data, analysed the data, and drafted the paper. JG conceptualized the study and assisted with study design, reviewed the paper. DN designed the serum antioxidant/oxidative stress studies, assisted with the study design, and reviewed the paper. OL conducted the serum antioxidant/oxidative stress assays, assisted with the study design and reviewed the paper. SS assisted with the organization of the study and the data collection, and reviewed the paper. SB organized the dispensing of the supplements and collected the compliance data, assisted with study design and reviewed the paper.
ME was responsible for serum collection and transport of serum to the laboratory, assisted with the organization of the data collection and reviewed the paper. CO assisted with study conceptualization and design and reviewed the paper.
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Batterham, M., Gold, J., Naidoo, D. et al. A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS. Eur J Clin Nutr 55, 107–114 (2001). https://doi.org/10.1038/sj.ejcn.1601124
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DOI: https://doi.org/10.1038/sj.ejcn.1601124
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