Ubiquitin chains have critical roles in activating the NF-κB pathway and mediating immune responses. Recent structural work on distinct ubiquitin chains in complexes with selective ubiquitin-binding domains provides an explanation for directionality and specificity in the NF-κB pathway.
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Dikic, I., Dötsch, V. Ubiquitin linkages make a difference. Nat Struct Mol Biol 16, 1209–1210 (2009). https://doi.org/10.1038/nsmb1209-1209
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DOI: https://doi.org/10.1038/nsmb1209-1209
