Much has been written and said about the links between the Ink4a-Arf locus, cellular senescence and stem-cell maintenance. Standing modestly in the shadows of these superstars of tumor suppression, the closely linked Ink4b gene is now emerging as a significant player in these events, and its regulation by a histone demethylase could provide new insights into how this remarkable locus is controlled.
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EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
Epigenetics & Chromatin Open Access 02 December 2009
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Peters, G. An INKlination for epigenetic control of senescence. Nat Struct Mol Biol 15, 1133–1134 (2008). https://doi.org/10.1038/nsmb1108-1133
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DOI: https://doi.org/10.1038/nsmb1108-1133
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