RNA interference (RNAi) is important in directing heterochromatin assembly at centromeres in fission yeast, which is crucial for maintaining a stable genome through mitotic and meiotic divisions. In this issue, Buker et al. describe a new Argonaute siRNA chaperone (ARC) that converts duplex RNA to single-stranded RNA. This is a previously unknown step in the RNAi-directed heterochromatin-formation pathway.
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Ekwall, K. 'Arc' escorts siRNAs in heterochromatin assembly. Nat Struct Mol Biol 14, 178–179 (2007). https://doi.org/10.1038/nsmb0307-178
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DOI: https://doi.org/10.1038/nsmb0307-178