BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type I topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bloom, D. Am. J. Dis. Child. 88, 754–758 (1954).
German, J. Medicine 72, 393–406 (1993).
Hickson, I.D. Nat. Rev. Cancer 3, 169–178 (2003).
Chaganti, R.S., Schonberg, S. & German, J. Proc. Natl. Acad. Sci. USA 71, 4508–4512 (1974).
Ira, G., Malkova, A., Liberi, G., Foiani, M. & Haber, J.E. Cell 115, 401–411 (2003).
Wu, L.J. & Hickson, I.D. Nature 426, 870–874 (2003).
Rockmill, B., Fung, J.C., Branda, S.S. & Roeder, G.S. Curr. Biol. 13, 1954–1962 (2003).
Nakayama, H. Oncogene 21, 9008–9021 (2002).
Wu, L., Davies, S.L., Levitt, N.C. & Hickson, I.D. J. Biol. Chem. 276, 19375–19381 (2001).
Braybrooke, J.P. et al. J. Biol. Chem. 278, 48357–48366 (2003).
Gangloff, S., de Massy, B., Arthur, L., Rothstein, R. & Fabre, F. EMBO J. 18, 1701–1711 (1999).
Moens, P.B. et al. J. Cell Sci. 115, 1611–1622 (2002).
Schwacha, A. & Kleckner, N. Cell 76, 51–63 (1994).
Carpenter, A.T.C. Proc. Natl. Acad. Sci. USA 79, 5961–5965 (1982).
Heyer, W.D., Ehmsen, K.T. & Solinger, J.A. Trends Biochem. Sci. 10, 548–557 (2003).
Gangloff, S., Soustelle, C. & Fabre, F. Nat. Genet. 25, 192–194 (2000).
Veaute, X. et al. Nature 423, 309–312 (2003).
Krejci, L. et al. Nature 423, 305–309 (2003).
Hanada, K. et al. Proc. Natl. Acad. Sci. USA 94, 3860–3865 (1997).
Adams, M.D., McVey, M. & Sekelsky, J.J. Science 299, 265–267 (2003).
van Brabant, A.J. et al. Biochemistry 39, 14617–14625 (2000).
Karow, J.K., Constantinou, A., Li, J.L., West, S.C. & Hickson, I.D. Proc. Natl. Acad. Sci. USA 97, 6504–6508 (2000).
Saintigny, Y., Makienko, K., Swanson, C., Edmond, M.J. & Monnat, R.J. Mol. Cell. Biol. 22, 6971–6978 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heyer, WD. A new deal for Holliday junctions. Nat Struct Mol Biol 11, 117–119 (2004). https://doi.org/10.1038/nsmb0204-117
Issue Date:
DOI: https://doi.org/10.1038/nsmb0204-117
